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Study · Randomized controlled trial · n = 77 · 2006

2 results

Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles.

Fitzgerald LM, Fryer JL, Dwyer T, Humphrey SM

Peptides15 Nov 2005Cited by 24 (Europe PMC)

PMID16293341 (opens in a new tab)DOI10.1016/j.peptides.2004.12.038 (opens in a new tab)PepBankPUB-16293341
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In Caucasian individuals, MELANOTAN (NDP-MSH) increased skin melanin density more than placebo.

    In plain wordsIn Caucasian adults, MELANOTAN raised skin melanin more than placebo.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMelanin density
    Study

    n = 77

    Comparator
    Placebo
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of MELANOTAN produced a significant (p<0.001) increase in melanin density in treated, compared to placebo, individuals.
    1 context sentence
    Summary · context
    In this study of 77 Caucasian individuals, we investigated the effects of MELANOTAN in individuals with variant MC1R genotypes, as it has been suggested through in vitro studies that variant alleles decrease MELANOTAN binding efficacy, which would subsequently affect the synthesis of melanin.
  2. 02HumanRandomized controlled trialEfficacy outcome

    MELANOTAN increased melanin density more in individuals with MC1R variants Val60Leu, Asp84Glu, Val92Met, Arg142His, Arg151Cys or Arg160Trp than in individuals with no variant alleles.

    In plain wordsMELANOTAN raised skin melanin more in people with certain MC1R gene variants than in people without them.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMelanin density in carriers of MC1R variant alleles
    Study

    n: not reported in source

    Comparator
    Individuals with no variant alleles
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, MELANOTAN increased the melanin density to a greater extent in individuals carrying the variant alleles Val60Leu, Asp84Glu, Val92Met, Arg142His, Arg151Cys, and Arg160Trp than in individuals with no variant alleles.
    1 context sentence
    Summary · context
    In this study of 77 Caucasian individuals, we investigated the effects of MELANOTAN in individuals with variant MC1R genotypes, as it has been suggested through in vitro studies that variant alleles decrease MELANOTAN binding efficacy, which would subsequently affect the synthesis of melanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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