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Study · Animal study (in vivo) · rhesus monkey · 2006

4 results

Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges.

Plant TM, Ramaswamy S, Dipietro MJ

Endocrinology10 Nov 2005Cited by 202 (Europe PMC)

PMID16282350 (opens in a new tab)DOI10.1210/en.2005-1261 (opens in a new tab)PepBankPUB-16282350
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In juvenile agonadal male rhesus monkeys, the first brief kisspeptin‑10 infusion evoked an LH discharge like those produced by GnRH priming.

    In plain wordsIn young male monkeys, the first kisspeptin‑10 infusion caused an LH surge like one caused by GnRH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH discharge after first kisspeptin-10 infusion
    Study

    rhesus monkeyn = 4

    Juvenile agonadal male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    2 microg as a 1-min infusion once every hour · intravenous · 48 hAs given in this study (rhesus monkey).

    Source sentences

    Summary
    The first brief infusion of kisspeptin-10 evoked an LH discharge that mimicked those produced by GnRH priming
    1 context sentence
    Summary · context
    Accordingly, we determined whether repetitive iv administration of the GPR54 receptor agonist kisspeptin-10 (2 microg as a brief 1-min infusion once every hour for 48 h) to the juvenile male rhesus monkey would prematurely elicit sustained, pulsatile release of hypothalamic GnRH, the neuroendocrine…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In juvenile agonadal male rhesus monkeys, hourly kisspeptin‑10 administration produced a train of similar LH discharges.

    In plain wordsIn young male monkeys, hourly kisspeptin‑10 caused repeated LH surges.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTrain of LH discharges with repetitive kisspeptin-10
    Study

    rhesus monkeyn = 4

    Juvenile agonadal male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    2 microg as a 1-min infusion once every hour · intravenous · 48 hAs given in this study (rhesus monkey).

    Source sentences

    Summary
    a train of similar LH discharges in response to hourly activation of GPR54 by repetitive kisspeptin-10 administration.
    1 context sentence
    Summary · context
    Accordingly, we determined whether repetitive iv administration of the GPR54 receptor agonist kisspeptin-10 (2 microg as a brief 1-min infusion once every hour for 48 h) to the juvenile male rhesus monkey would prematurely elicit sustained, pulsatile release of hypothalamic GnRH, the neuroendocrine…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In juvenile agonadal male rhesus monkeys, repetitive kisspeptin‑10 administration also provided a GnRH-dependent signal to FSH secretion.

    In plain wordsIn young male monkeys, repeated kisspeptin‑10 also drove FSH release, through GnRH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFSH secretion with repetitive kisspeptin-10
    Study

    rhesus monkeyn = 4

    Juvenile agonadal male rhesus monkey (Macaca mulatta)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    2 microg as a 1-min infusion once every hour · intravenous · 48 hAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Repetitive kisspeptin-10 administration also provided a GnRH-dependent signal to FSH secretion.
    1 context sentence
    Summary · context
    Accordingly, we determined whether repetitive iv administration of the GPR54 receptor agonist kisspeptin-10 (2 microg as a brief 1-min infusion once every hour for 48 h) to the juvenile male rhesus monkey would prematurely elicit sustained, pulsatile release of hypothalamic GnRH, the neuroendocrine…

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In juvenile male rhesus monkeys, concomitant treatment with the GnRH receptor antagonist acyline abolished kisspeptin‑10-induced LH release.

    In plain wordsIn young male monkeys, a GnRH blocker stopped the LH release that kisspeptin‑10 caused.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH release with kisspeptin-10 plus GnRH receptor antagonist acyline
    Study

    rhesus monkeyn: not reported in source

    Juvenile agonadal male rhesus monkey (Macaca mulatta)
    Comparator
    Kisspeptin-10 without acyline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Concomitant treatment with a GnRH receptor antagonist, acyline, abolished kisspeptin-10-induced LH release.
    1 context sentence
    Summary · context
    Accordingly, we determined whether repetitive iv administration of the GPR54 receptor agonist kisspeptin-10 (2 microg as a brief 1-min infusion once every hour for 48 h) to the juvenile male rhesus monkey would prematurely elicit sustained, pulsatile release of hypothalamic GnRH, the neuroendocrine…

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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