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Study · Observational study · n = 37 · 2005

2 results

Constitutional delayed puberty in males and hypogonadotropic hypogonadism: a reliable and cost-effective approach to differential diagnosis.

Martin MM, Martin AL

Journal of pediatric endocrinology & metabolism : JPEM1 Sept 2005Cited by 7 (Europe PMC)

PMID16279369 (opens in a new tab)DOI10.1515/jpem.2005.18.9.909 (opens in a new tab)PepBankPUB-16279369
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanObservational studyActivity measurement

    In male teenagers with constitutional delayed puberty, 34 were properly diagnosed with an LH response to GnRH above 12 IU/l, and three did not reach that level.

    In plain wordsIn teenage boys with constitutional delayed puberty, 34 had an LH response to GnRH above 12 IU/l and three did not.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableLH response to GnRH in constitutional delayed puberty
    Study

    n = 37

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.1 mg · intravenousAs given in this study (human).

    Measurements

    LH response lower limit
    12 IU/l
    constitutional delayed puberty

    Source sentences

    Summary
    At referral 34 youngsters with CDP were properly diagnosed when the lower limit for the luteinizing hormone (LH) response to GnRH (Factrel 0.1 mg i.v.) was set at 12 IU/l. Three boys with CDP failed to reach that level and were not assigned appropriately.
    1 context sentence
    Summary · context
    Forty-six male teenagers 13-19 years old with delayed puberty (DP) underwent gonadotropin releasing hormone (GnRH) and human chorionic gonadotropin (HCG) stimulation as part of their work-up.
  2. 02HumanObservational studyActivity measurement

    In male teenagers with hypogonadotropic hypogonadism, all nine had LH responses to GnRH stimulation below 8.0 IU/l.

    In plain wordsIn teenage boys with hypogonadotropic hypogonadism, all nine had an LH response to GnRH below 8.0 IU/l.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableLH response to GnRH in hypogonadotropic hypogonadism
    Study

    n = 9

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.1 mg · intravenousAs given in this study (human).

    Measurements

    LH response
    < 8 IU/l
    hypogonadotropic hypogonadism

    Source sentences

    Summary
    All nine patients with HH had basal serum testosterone (T) < 50 ng/dl when first seen and LH responses to GnRH stimulation < 8.0 IU/l
    1 context sentence
    Summary · context
    Forty-six male teenagers 13-19 years old with delayed puberty (DP) underwent gonadotropin releasing hormone (GnRH) and human chorionic gonadotropin (HCG) stimulation as part of their work-up.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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