Differences in serum LH and FSH levels using depot or daily GnRH agonists in controlled ovarian stimulation: influence on ovarian response and outcome of ART.

Sonntag B, Kiesel L, Nieschlag E, Behre HM

Journal of assisted reproduction and genetics1 Aug 2005Cited by 9 (Europe PMC)

PMID16195824DOI10.1007/s10815-005-5998-8PepBankPUB-16195824

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialEfficacy outcome
In ART patients, depot triptorelin produced lower serum LH after downregulation than daily triptorelin.
In plain wordsIn ART patients, depot triptorelin produced lower LH levels than daily triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum LH after downregulation
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depot versus 0.1 mg dailyAs given in this study (human).
Source sentences
Summary
After downregulation serum LH and FSH levels were significantly lower in group I.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
Report a problemFND-1619582401
02HumanNon-randomized trialEfficacy outcome
In ART patients, depot triptorelin produced lower serum FSH after downregulation than daily triptorelin.
In plain wordsIn ART patients, depot triptorelin produced lower FSH levels than daily triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum FSH after downregulation
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depot versus 0.1 mg dailyAs given in this study (human).
Source sentences
Summary
After downregulation serum LH and FSH levels were significantly lower in group I.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
Report a problemFND-1619582402

Studies that did not test the peptide alone6

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In ART patients, depot triptorelin required higher FSH stimulation doses than daily triptorelin.
In plain wordsIn ART patients, depot triptorelin required higher FSH doses than daily triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFSH stimulation dose requirement
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Patients of group I needed significantly higher FSH doses to achieve comparable levels of serum estradiol and preovulatory follicles.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1619582403
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In ART patients, depot and daily triptorelin protocols achieved comparable serum estradiol levels with different FSH doses.
In plain wordsIn ART patients, depot and daily triptorelin protocols achieved comparable estradiol levels with different FSH doses.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeSerum estradiol during stimulation
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Patients of group I needed significantly higher FSH doses to achieve comparable levels of serum estradiol and preovulatory follicles.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1619582404
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In ART patients, depot and daily triptorelin protocols achieved comparable preovulatory follicles with different FSH doses.
In plain wordsIn ART patients, depot and daily triptorelin protocols achieved comparable preovulatory follicles with different FSH doses.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePreovulatory follicles
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Patients of group I needed significantly higher FSH doses to achieve comparable levels of serum estradiol and preovulatory follicles.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1619582405
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In ART patients, depot triptorelin yielded fewer retrieved oocytes than daily triptorelin.
In plain wordsIn ART patients, depot triptorelin yielded fewer retrieved eggs than daily triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseRetrieved oocytes
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The number of retrieved oocytes and transferable embryos was lower in group I.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1619582406
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In ART patients, depot triptorelin yielded fewer transferable embryos than daily triptorelin.
In plain wordsIn ART patients, depot triptorelin yielded fewer transferable embryos than daily triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseTransferable embryos
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The number of retrieved oocytes and transferable embryos was lower in group I.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1619582407
08HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In ART patients, the depot triptorelin protocol had a lower fertilization rate than the daily triptorelin protocol.
In plain wordsIn ART patients, fertilization rates were lower with depot triptorelin than with daily triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFertilization rate
Study
n = 81
Comparator
Daily triptorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Patients with profound endogenous LH suppression by depot GnRH agonists show higher FSH stimulation dose requirements and lower oocyte number and fertilization rate, indicating a need for minimal LH activity in folliculogenesis and oocyte development.
1 context sentence(design, population, supporting numbers)
Summary · context
Group I (n = 27) received 3.75 mg of the GnRH agonist triptorelin acetate depot, group II (n = 54) was given 0.1 mg triptorelin acetate daily, followed by ovarian stimulation with recombinant FSH.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1619582408

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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