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Study · Measured the body's own peptide · 2005

3 results

Expression of thymosin beta4 mRNA by activated microglia in the denervated hippocampus.

Dong JH, Ying GX, Liu X, Wang WY, Wang Y, Ni ZM, Zhou CF

Neuroreport1 Oct 2005Cited by 11 (Europe PMC)

PMID16189468 (opens in a new tab)DOI10.1097/01.wnr.0000183326.21241.48 (opens in a new tab)PepBankPUB-16189468
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    After entorhinal deafferentation, Northern blotting showed a transient increase of thymosin beta4 mRNA in the hippocampus versus controls, peaking at 3 days post-lesion.

    In plain wordsIn animals with a nerve-pathway lesion, the body's own thymosin beta4 mRNA rose briefly in the hippocampus compared with controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta4 mRNA in the deafferented hippocampus
    Study

    n: not reported in source

    hippocampus after entorhinal deafferentation
    Comparator
    Controls
    Outcome group
    Gene expression · Nervous system and cognition

    Measurements

    mRNA fold of controls
    1.8 fold
    1 day post-lesion
    mRNA fold of controls
    2.3 fold
    3 days post-lesion
    mRNA fold of controls
    1.3 fold
    7 days post-lesion
    mRNA fold of controls
    1.1 fold
    15 days post-lesion

    Source sentences

    Summary
    Northern blotting displayed a transient increase of thymosin beta4 mRNA in the deafferented hippocampus by 1.8, 2.3, 1.3 and 1.1-fold of controls, respectively, at 1, 3, 7 and 15 days post-lesion.
    1 context sentence
    Summary · context
    Here, we report a prominent upregulation of thymosin beta4 in the hippocampus following entorhinal deafferentation.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In-situ hybridization confirmed that induction of thymosin beta4 mRNA occurred specifically in the entorhinally denervated zones of the hippocampus.

    In plain wordsIn animals with a nerve-pathway lesion, the rise in the body's own thymosin beta4 mRNA occurred in the denervated zones of the hippocampus.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableLocation of thymosin beta4 mRNA induction in hippocampus
    Study

    n: not reported in source

    hippocampus after entorhinal deafferentation
    Outcome group
    Gene expression · Nervous system and cognition

    Source sentences

    Summary
    In-situ hybridization confirmed that the induction of thymosin beta4 mRNA specifically occurred in the entorhinally denervated zones of the hippocampus.
    1 context sentence
    Summary · context
    Here, we report a prominent upregulation of thymosin beta4 in the hippocampus following entorhinal deafferentation.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    Double labeling showed that isolectin B4-positive microglial cells are responsible for deafferentation-induced thymosin beta4 mRNA expression.

    In plain wordsIn animals with a nerve-pathway lesion, microglial cells were the source of the extra body's own thymosin beta4 mRNA.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCell type that expresses thymosin beta4 mRNA after deafferentation
    Study

    n: not reported in source

    hippocampus after entorhinal deafferentation
    Outcome group
    Gene expression · Nervous system and cognition

    Source sentences

    Summary
    The double labeling of in-situ hybridization for thymosin beta4 mRNA with isolectin B4 cytochemistry showed that isolectin B4-positive microglial cells are responsible for deafferentation-induced thymosin beta4 mRNA expression.
    1 context sentence
    Summary · context
    Here, we report a prominent upregulation of thymosin beta4 in the hippocampus following entorhinal deafferentation.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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