Effect of methylene blue on middle cerebral artery flow velocity in a patient with severe sepsis following clipping of a cerebral aneurysm.

Zygun DA, Bradley PG, Menon DK

Neurocritical care1 Jan 2005Cited by 4 (Europe PMC)

PMID16174966DOI10.1385/ncc:2:1:039PepBankPUB-16174966

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanCase report or seriesEfficacy outcome
In a patient with severe sepsis after aneurysm clipping, methylene blue rapidly increased mean arterial pressure.
In plain wordsIn a patient with severe sepsis after aneurysm surgery, methylene blue rapidly increased blood pressure.
Peptide
Methylene blue
Outcome
IncreaseMean arterial pressure
Study
n = 1
Outcome group
Blood pressure · Cardiovascular
Studied dose
2 milligrams/kilograms · intravenousAs given in this study (human).
Source sentences
Summary
The effect of methylene blue on mean arterial pressure occurred quite rapidly after initiation of the infusion, allowing downward titration of norepinephrine.
3 context sentences(design, population, supporting numbers)
Summary · context
Initially, FVm increased in association with an increase in mean arterial pressure, reaching its highest value halfway through the infusion.
Summary · context
This article presents a case report of a 58-year old-female with a clinical presentation compatible with severe sepsis and increasing inotropic requirements following clipping of a cerebral aneurysm.
Summary · context
Administration of methylene blue (2 milligrams/kilograms) intravenously was undertaken with monitoring of mean arterial pressure and middle cerebral artery flow velocity (FVm).
Report a problemFND-1617496601
02HumanCase report or seriesEfficacy outcome
In a patient with severe sepsis after aneurysm clipping, methylene blue allowed reduction of norepinephrine.
In plain wordsIn a patient with severe sepsis after aneurysm surgery, methylene blue allowed a lower norepinephrine dose.
Peptide
Methylene blue
Outcome
DecreaseNorepinephrine requirement
Study
n = 1
Outcome group
Intensive care and hospital outcomes · Cardiovascular
Studied dose
2 milligrams/kilograms · intravenousAs given in this study (human).
Source sentences
Summary
The effect of methylene blue on mean arterial pressure occurred quite rapidly after initiation of the infusion, allowing downward titration of norepinephrine.
2 context sentences(design, population, supporting numbers)
Summary · context
This article presents a case report of a 58-year old-female with a clinical presentation compatible with severe sepsis and increasing inotropic requirements following clipping of a cerebral aneurysm.
Summary · context
Administration of methylene blue (2 milligrams/kilograms) intravenously was undertaken with monitoring of mean arterial pressure and middle cerebral artery flow velocity (FVm).
Report a problemFND-1617496602
03HumanCase report or seriesEfficacy outcome
In a patient with severe sepsis, cerebral artery flow velocity initially increased during methylene blue infusion, then returned to baseline.
In plain wordsIn a patient with severe sepsis, brain artery flow speed rose during methylene blue infusion, then returned to baseline.
Peptide
Methylene blue
Outcome
MixedMiddle cerebral artery flow velocity
Study
n = 1
Outcome group
Cerebral blood flow · Cardiovascular
Studied dose
2 milligrams/kilograms · intravenousAs given in this study (human).
Source sentences
Summary
Initially, FVm increased in association with an increase in mean arterial pressure, reaching its highest value halfway through the infusion.
3 context sentences(design, population, supporting numbers)
Summary · context
Subsequently, FVm decreased to baseline by the end of the monitoring period.
Summary · context
This article presents a case report of a 58-year old-female with a clinical presentation compatible with severe sepsis and increasing inotropic requirements following clipping of a cerebral aneurysm.
Summary · context
Administration of methylene blue (2 milligrams/kilograms) intravenously was undertaken with monitoring of mean arterial pressure and middle cerebral artery flow velocity (FVm).
Report a problemFND-1617496603
04HumanCase report or seriesEfficacy outcome
In a patient with severe sepsis, cerebral vascular resistance fell during methylene blue infusion under an assumption about intracranial pressure, with the insonated vessel diameter reported as unchanged.
In plain wordsIn a patient with severe sepsis, estimated brain vessel resistance fell during methylene blue infusion, based on an assumption about pressure inside the skull.
Peptide
Methylene blue
Outcome
DecreaseCerebral vascular resistance
Study
n = 1
Outcome group
Cerebral blood flow · Cardiovascular
Studied dose
2 milligrams/kilograms · intravenousAs given in this study (human).
Source sentences
Summary
The rise in mean arterial pressure and increase in FVm were accompanied by a reductionin cerebral vascular resistance assuming intracranial pressure, and the diameter of the insonated vessel was unchanged during and immediately after infusion of methylene blue.
2 context sentences(design, population, supporting numbers)
Summary · context
This article presents a case report of a 58-year old-female with a clinical presentation compatible with severe sepsis and increasing inotropic requirements following clipping of a cerebral aneurysm.
Summary · context
Administration of methylene blue (2 milligrams/kilograms) intravenously was undertaken with monitoring of mean arterial pressure and middle cerebral artery flow velocity (FVm).
Report a problemFND-1617496604

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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