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Study · Measured the body's own peptide · 2005

6 results

Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase.

Wang D, Li H, Yuan H, Zheng M, Bai C, Chen L, Pei X

Apoptosis : an international journal on programmed cell death1 Oct 2005Cited by 44 (Europe PMC)

PMID16151632 (opens in a new tab)DOI10.1007/s10495-005-1191-x (opens in a new tab)PepBankPUB-16151632
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In K562 cells, serum deprivation decreased the expression of the body's own humanin.

    In plain wordsIn K562 cells, removing serum lowered the cells' own humanin levels.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin expression after serum deprivation
    Study

    n: not reported in source

    K562 cells
    Outcome group
    Cell viability and death · Cancer

    Source sentences

    Summary
    Upon serum deprivation, expression of HN in K562 cells decreased and its intracellular distribution changed from cytoplasm to cell membrane.
    1 context sentence
    Summary · context
    In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In K562 cells, serum deprivation shifted the intracellular distribution of the body's own humanin from the cytoplasm to the cell membrane.

    In plain wordsIn K562 cells, removing serum moved the cells' own humanin from the cytoplasm to the cell membrane.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin intracellular distribution after serum deprivation
    Study

    n: not reported in source

    K562 cells
    Outcome group
    Cell viability and death · Cancer

    Source sentences

    Summary
    Upon serum deprivation, expression of HN in K562 cells decreased and its intracellular distribution changed from cytoplasm to cell membrane.
    1 context sentence
    Summary · context
    In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 03LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In K562 cells stably transfected with the humanin gene, apoptosis was delayed compared with control vector transfected cells.

    In plain wordsIn K562 cells carrying extra humanin genes, cell death was delayed compared with control cells.

    Peptide
    Humanin
    Outcome
    DecreaseApoptosis after serum deprivation in cells overexpressing humanin
    Study

    n: not reported in source

    K562 cells
    Comparator
    Control vector transfected cells
    Outcome group
    Cell viability and death · Cancer

    Source sentences

    Summary
    In HN stably transfected K562 cells, apoptosis was delayed compared with control vector transfected cells as measured by flow cytometry.
    1 context sentence
    Summary · context
    In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 04LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In K562 cells transfected with the humanin gene, p38 activation after serum deprivation was suppressed.

    In plain wordsIn K562 cells carrying extra humanin genes, p38 activation after serum removal was weaker.

    Peptide
    Humanin
    Outcome
    Decreasep38 activation in humanin transfected cells
    Study

    n: not reported in source

    K562 cells
    Comparator
    Control vector transfected cells
    Outcome group
    Cell viability and death · Cancer

    Source sentences

    Summary
    And in HN transfected K562 cells, ERK downregulation was not affected, but p38 activation was suppressed, which may responsible for the delayed apoptosis in these cells.
    1 context sentence
    Summary · context
    In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 05LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In K562 cells transfected with the humanin gene, ERK downregulation after serum deprivation was not affected.

    In plain wordsIn K562 cells carrying extra humanin genes, the drop in ERK activity after serum removal did not change.

    Peptide
    Humanin
    Outcome
    No significant changeERK downregulation in humanin transfected cells
    Study

    n: not reported in source

    K562 cells
    Comparator
    Control vector transfected cells
    Outcome group
    Cell viability and death · Cancer

    Source sentences

    Summary
    And in HN transfected K562 cells, ERK downregulation was not affected, but p38 activation was suppressed, which may responsible for the delayed apoptosis in these cells.
    1 context sentence
    Summary · context
    In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 06LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In K562 cells, overexpression of the humanin gene reduced megakaryocytic differentiation.

    In plain wordsIn K562 cells, extra humanin gene activity reduced the cells' change into megakaryocyte-like cells.

    Peptide
    Humanin
    Outcome
    DecreaseMegakaryocytic differentiation with humanin overexpression
    Study

    n: not reported in source

    K562 cells
    Outcome group
    Cell viability and death · Cancer

    Source sentences

    Summary
    Additionally, overexpression of HN reduced megakaryocytic differentiation of K562 cells.
    1 context sentence
    Summary · context
    In this study, we investigated its antiapoptotic effect and the potential mechanisms in K562 cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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