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Study · Animal study (in vivo) · mouse · 2005

2 results

Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment.

King A, Lock J, Xu G, Bonner-Weir S, Weir GC

Diabetologia23 Aug 2005Cited by 64 (Europe PMC)

PMID16132945 (opens in a new tab)DOI10.1007/s00125-005-1922-0 (opens in a new tab)PepBankPUB-16132945
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice receiving islet transplants, recipient exendin‑4 treatment did not benefit glucose homeostasis versus vehicle.

    In plain wordsIn diabetic mice with islet transplants, exendin‑4 treatment did not improve blood sugar control compared with vehicle.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeGlucose homeostasis after recipient treatment
    Study

    mousen: not reported in source

    Diabetic mice receiving islet transplants
    Comparator
    Vehicle
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    The treatment of the recipient mice with exendin-4 did not have beneficial effects on glucose homeostasis.
    2 context sentences
    Summary · context
    Seventy-five fresh islets were transplanted to the right kidney of diabetic mice and 425 fresh islets were transplanted to the left kidney.
    Summary · context
    The mice were treated with exendin-4 or vehicle for 14 days, after which the large graft was removed by left nephrectomy.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, islets cultured with exendin‑4 increased hyperglycemia reversal relative to untreated cultured islets, but remained less effective than fresh islets.

    In plain wordsIn diabetic mice, exendin‑4-treated cultured islets reversed high blood sugar more often than untreated cultured islets, but less than fresh islets.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseHyperglycemia reversal after islet culture treatment
    Study

    mousen: not reported in source

    Diabetic mice receiving islet transplants
    Comparator
    Islets cultured without exendin-4
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 72 h islet cultureAs given in this study (mouse).

    Source sentences

    Summary
    However, when islets are cultured, exendin-4 treatment increases the rate of reversal of hyperglycaemia, but not to the degree of fresh islets.
    1 context sentence
    Summary · context
    In a separate set of experiments, islets cultured in the presence or absence of exendin-4 for 72 h, or fresh islets, were transplanted to diabetic mice.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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