Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats.

Lazić R, Gabrić N, Dekaris I, Bosnar D, Boban-Blagaić A, Sikirić P

Collegium antropologicum1 Jun 2005Cited by 24 (Europe PMC)

PMID16117343PepBankPUB-16117343

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with corneal epithelial debridement, topical BPC‑157 at microg or ng doses markedly accelerated recovery of the defect versus control.
In plain wordsIn rats with corneal injury, BPC‑157 eye drops sped up healing of the eye surface compared with water.
Peptide
BPC-157
Outcome
IncreaseRecovery of corneal epithelial defect
Study
ratn: not reported in source
Corneal epithelial debridement
Comparator
Distilled water
Outcome group
Wound healing · Eye
Studied dose
2 microg/ml, 2 ng/ml · topical · up to 40 hoursAs given in this study (rat).
Source sentences
Summary
Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e.,…
Report a problemFND-1611734301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with corneal epithelial debridement, lesions treated with BPC‑157 at the microg dose disappeared by 40 h, while control lesions were still present at 48 h.
In plain wordsIn rats with corneal injury, lesions treated with BPC‑157 eye drops healed by 40 hours; water-group lesions stayed open at 48 hours.
Peptide
BPC-157
Outcome
DecreaseTime to disappearance of lesion, microg dose
Study
ratn: not reported in source
Corneal epithelial debridement
Comparator
Distilled water
Outcome group
Wound healing · Eye
Studied dose
2 microg/ml · topical · up to 40 hoursAs given in this study (rat).
Measurements
Time to lesion disappearance
40 h
BPC 157 2 microg/ml
Source sentences
Summary
Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e.,…
Report a problemFND-1611734302
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with corneal epithelial debridement, lesions treated with BPC‑157 at the ng dose disappeared by 48 h, while control lesions were still present at 48 h.
In plain wordsIn rats with corneal injury, lesions treated with lower-dose BPC‑157 eye drops healed by 48 hours; water-group lesions stayed open.
Peptide
BPC-157
Outcome
DecreaseTime to disappearance of lesion, ng dose
Study
ratn: not reported in source
Corneal epithelial debridement
Comparator
Distilled water
Outcome group
Wound healing · Eye
Studied dose
2 ng/ml · topical · up to 40 hoursAs given in this study (rat).
Measurements
Time to lesion disappearance
48 h
BPC 157 2 ng/ml
Source sentences
Summary
Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e.,…
Report a problemFND-1611734303
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with corneal epithelial debridement, the effect of topical BPC‑157 on healing of the defect was dose dependent.
In plain wordsIn rats with corneal injury, the healing effect of BPC‑157 eye drops depended on the dose.
Peptide
BPC-157
Outcome
MixedDose dependence of corneal defect healing
Study
ratn: not reported in source
Corneal epithelial debridement
Comparator
Distilled water
Outcome group
Wound healing · Eye
Studied dose
2 pg/ml, 2 ng/ml, 2 microg/ml · topical · up to 40 hoursAs given in this study (rat).
Source sentences
Summary
Results were dose dependent.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h).
Report a problemFND-1611734304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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