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Study · Non-randomized trial · n = 17 · 2005

5 results

Inhaled glutathione decreases PGE2 and increases lymphocytes in cystic fibrosis lungs.

Hartl D, Starosta V, Maier K, Beck-Speier I, Rebhan C, Becker BF, Latzin P, Fischer R, Ratjen F, Huber RM, Rietschel E, Krauss-Etschmann S, Griese M

Free radical biology & medicine14 Apr 2005Cited by 50 (Europe PMC)

PMID16043018 (opens in a new tab)DOI10.1016/j.freeradbiomed.2005.03.032 (opens in a new tab)PepBankPUB-16043018
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialMechanism

    In cystic fibrosis, inhaled glutathione significantly decreased bronchoalveolar lavage PGE2 compared with pretreatment levels.

    In plain wordsIn cystic fibrosis, inhaled glutathione significantly decreased lung lavage PGE2 compared with pretreatment levels.

    Peptide
    Glutathione
    Outcome
    DecreaseBALF PGE2
    Study

    n = 17

    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · inhalationAs given in this study (human).

    Source sentences

    Summary
    Inhalation of GSH decreased BALF levels of PGE2 and increased CD4+ and CD8+ lymphocytes in BALF significantly but had no effect on markers of oxidative stress.
    2 context sentences
    Summary · context
    BALF from 17 CF patients (median FEV1 67% (43-105%) of predicted) was assessed before and after GSH inhalation for total protein, markers of oxidative stress (8-isoprostane, myeloperoxidase, and ascorbic and uric acid), pattern of protein oxidation, prostaglandin E2 (PGE2), and proinflammatory cytokines.
    Summary · context
    BALF cells were differentiated using cytospin slides, and lymphocytes were further analyzed by flow cytometry.
  2. 02HumanNon-randomized trialMechanism

    In cystic fibrosis, inhaled glutathione significantly increased bronchoalveolar lavage CD4+ lymphocytes compared with pretreatment levels.

    In plain wordsIn cystic fibrosis, inhaled glutathione significantly increased lung lavage CD4+ immune cells compared with pretreatment levels.

    Peptide
    Glutathione
    Outcome
    IncreaseBALF CD4+ lymphocytes
    Study

    n = 17

    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated · inhalationAs given in this study (human).

    Source sentences

    Summary
    Inhalation of GSH decreased BALF levels of PGE2 and increased CD4+ and CD8+ lymphocytes in BALF significantly but had no effect on markers of oxidative stress.
    2 context sentences
    Summary · context
    BALF from 17 CF patients (median FEV1 67% (43-105%) of predicted) was assessed before and after GSH inhalation for total protein, markers of oxidative stress (8-isoprostane, myeloperoxidase, and ascorbic and uric acid), pattern of protein oxidation, prostaglandin E2 (PGE2), and proinflammatory cytokines.
    Summary · context
    BALF cells were differentiated using cytospin slides, and lymphocytes were further analyzed by flow cytometry.
  3. 03HumanNon-randomized trialMechanism

    In cystic fibrosis, inhaled glutathione significantly increased bronchoalveolar lavage CD8+ lymphocytes compared with pretreatment levels.

    In plain wordsIn cystic fibrosis, inhaled glutathione significantly increased lung lavage CD8+ immune cells compared with pretreatment levels.

    Peptide
    Glutathione
    Outcome
    IncreaseBALF CD8+ lymphocytes
    Study

    n = 17

    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated · inhalationAs given in this study (human).

    Source sentences

    Summary
    Inhalation of GSH decreased BALF levels of PGE2 and increased CD4+ and CD8+ lymphocytes in BALF significantly but had no effect on markers of oxidative stress.
    2 context sentences
    Summary · context
    BALF from 17 CF patients (median FEV1 67% (43-105%) of predicted) was assessed before and after GSH inhalation for total protein, markers of oxidative stress (8-isoprostane, myeloperoxidase, and ascorbic and uric acid), pattern of protein oxidation, prostaglandin E2 (PGE2), and proinflammatory cytokines.
    Summary · context
    BALF cells were differentiated using cytospin slides, and lymphocytes were further analyzed by flow cytometry.
  4. 04HumanNon-randomized trialMechanism

    In cystic fibrosis, inhaled glutathione did not change oxidative stress markers compared with pretreatment levels.

    In plain wordsIn cystic fibrosis, inhaled glutathione did not change oxidative stress markers compared with pretreatment levels.

    Peptide
    Glutathione
    Outcome
    No significant changeOxidative stress markers
    Study

    n = 17

    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    Dose not stated · inhalationAs given in this study (human).

    Source sentences

    Summary
    Inhalation of GSH decreased BALF levels of PGE2 and increased CD4+ and CD8+ lymphocytes in BALF significantly but had no effect on markers of oxidative stress.
    2 context sentences
    Summary · context
    BALF from 17 CF patients (median FEV1 67% (43-105%) of predicted) was assessed before and after GSH inhalation for total protein, markers of oxidative stress (8-isoprostane, myeloperoxidase, and ascorbic and uric acid), pattern of protein oxidation, prostaglandin E2 (PGE2), and proinflammatory cytokines.
    Summary · context
    BALF cells were differentiated using cytospin slides, and lymphocytes were further analyzed by flow cytometry.
  5. 05HumanNon-randomized trialMechanism

    In cystic fibrosis, the greatest lung function improvement after glutathione treatment was linked to the largest PGE2 decline.

    In plain wordsIn cystic fibrosis, the greatest lung function improvement after glutathione treatment was linked to the largest PGE2 decline.

    Peptide
    Glutathione
    Outcome
    DecreasePGE2 decline association with lung function improvement
    Study

    n = 17

    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · inhalationAs given in this study (human).

    Source sentences

    Summary
    The patients with the greatest improvement in lung function after GSH treatment also had the largest decline in PGE2 levels.
    2 context sentences
    Summary · context
    BALF from 17 CF patients (median FEV1 67% (43-105%) of predicted) was assessed before and after GSH inhalation for total protein, markers of oxidative stress (8-isoprostane, myeloperoxidase, and ascorbic and uric acid), pattern of protein oxidation, prostaglandin E2 (PGE2), and proinflammatory cytokines.
    Summary · context
    BALF cells were differentiated using cytospin slides, and lymphocytes were further analyzed by flow cytometry.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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