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Study · Not a test of the peptide alone · 2005

3 results

Molecular cloning and structural characterization of the functional human thymosin beta4 gene.

Yang SP, Lee HJ, Su Y

Molecular and cellular biochemistry1 Apr 2005Cited by 11 (Europe PMC)

PMID16010977 (opens in a new tab)DOI10.1007/s11010-005-7642-4 (opens in a new tab)PepBankPUB-16010977
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In SW480 cells, the -437 to +29 region of the human Tbeta4 gene showed significant promoter activity although it lacks TATA and CCAAT boxes.

    In plain wordsIn human colorectal cancer cells, a region of the Tbeta4 gene showed promoter activity without TATA or CCAAT boxes.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicablePromoter activity of the human Tbeta4 5'-flanking region
    Study

    humann: not reported in source

    SW480 colorectal carcinoma cells, CAT reporter
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Significant promoter activity was found in the -437 to +29 region of hTbeta4 gene even though it lacks both TATA and CCAAT boxes.
    1 context sentence
    Summary · context
    Expression of the chloramphenicol acetyltransferase (CAT) reporter constructs directed by various parts of the 5'-flanking region of this gene was evaluated by transient transfection assays using human colorectal carcinoma SW480 cells as hosts.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    No cis-element responsible for PMA-induced Tbeta4 gene expression was identified within the 1.5-kb 5'-flanking region.

    In plain wordsIn human colorectal cancer cells, no PMA-responsive control element was found in the 1.5-kb region upstream of the Tbeta4 gene.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changePMA-induced expression elements in the Tbeta4 5'-flanking region
    Study

    humann: not reported in source

    SW480 colorectal carcinoma cells, CAT reporter
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    However, cis-element(s) responsible for PMA-induced expression of Tbeta4 gene was not identified within its 1.5-kb 5'-flanking region.
    1 context sentence
    Summary · context
    Expression of the chloramphenicol acetyltransferase (CAT) reporter constructs directed by various parts of the 5'-flanking region of this gene was evaluated by transient transfection assays using human colorectal carcinoma SW480 cells as hosts.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    The human Tbeta4 gene has three exons and two introns spread over 2 kb, with its transcription start site 72 bp upstream of the initiation codon.

    In plain wordsIn lab tests, the human Tbeta4 gene was found to have three exons and two introns.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableStructure of the human Tbeta4 gene
    Study

    humann: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    gene length
    2 kb
    human Tbeta4 gene
    transcription start site upstream of initiation codon
    72 bp
    human Tbeta4 gene

    Source sentences

    Summary
    Human Tbeta4 gene comprises three exons and two introns distributed over 2 kb with its transcription start site at 72 bp upstream of the initiation codon.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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