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Study · In vitro (cells) · 2005

2 results

Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.

Hashimoto Y, Suzuki H, Aiso S, Niikura T, Nishimoto I, Matsuoka M

Life sciences6 Jul 2005Cited by 94 (Europe PMC)

PMID16005025 (opens in a new tab)DOI10.1016/j.lfs.2005.03.031 (opens in a new tab)PepBankPUB-16005025
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In F11 neurohybrid cells, neuroprotection by humanin was mediated by the STAT3 transcription factor and by certain tyrosine kinases.

    In plain wordsIn lab nerve cells, humanin's protection depended on the STAT3 protein and certain tyrosine kinase enzymes.

    Peptide
    Humanin
    Outcome
    Not applicableRole of STAT3 and tyrosine kinases in HN neuroprotection
    Study

    n: not reported in source

    F11 neurohybrid cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We simultaneously provide evidence that neuroprotection by HN in F11 cells is mediated by the STAT3 transcription factor as well as by certain tyrosine kinases.

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 02LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In neuronal cells, siRNA disruption of FPR2 expression did not attenuate humanin-mediated rescue of neuronal cell death induced by Alzheimer's disease-related insults.

    In plain wordsIn nerve cells, switching off the FPR2 receptor gene did not weaken the protection humanin gave against cell death.

    Peptide
    Humanin
    Outcome
    No significant changeHN-mediated rescue after FPR2 siRNA knockdown
    Study

    n: not reported in source

    F11 neurohybrid cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    We here show that siRNA-mediated disruption of expression of the mouse counterpart of FPRL-1, FPR2, did not result in attenuation of HN-mediated rescue of neuronal cell death induced by AD-related insults.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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