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Study · Animal study (in vivo) · mouse · 2005

9 results

Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury.

Sosne G, Christopherson PL, Barrett RP, Fridman R

Investigative ophthalmology & visual science1 Jul 2005Cited by 91 (Europe PMC)

PMID15980226 (opens in a new tab)DOI10.1167/iovs.04-1368 (opens in a new tab)PepBankPUB-15980226
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with corneal alkali injury, topical Tbeta4 improved corneal clarity at day 7 compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 eye treatment gave clearer corneas at day 7 than PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCorneal clarity at day 7 after injury
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Tbeta4-treated corneas demonstrated improved corneal clarity at day 7 PI.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with corneal alkali injury, topical Tbeta4 decreased corneal MMP-2 levels compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 lowered the enzyme MMP-2 in the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCorneal MMP-2 level
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Whereas Tbeta4 decreased corneal MMP-2 and -9 and MT6-MMP levels after alkali injury, no change in TIMP-1 and -2 expression was detected.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with corneal alkali injury, topical Tbeta4 decreased corneal MMP-9 levels compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 lowered the enzyme MMP-9 in the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCorneal MMP-9 level
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Whereas Tbeta4 decreased corneal MMP-2 and -9 and MT6-MMP levels after alkali injury, no change in TIMP-1 and -2 expression was detected.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with corneal alkali injury, topical Tbeta4 decreased corneal MT6-MMP levels compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 lowered the enzyme MT6-MMP in the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCorneal MT6-MMP level
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Whereas Tbeta4 decreased corneal MMP-2 and -9 and MT6-MMP levels after alkali injury, no change in TIMP-1 and -2 expression was detected.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with corneal alkali injury, topical Tbeta4 did not change TIMP-1 expression compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 did not change TIMP-1 in the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCorneal TIMP-1 expression
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Whereas Tbeta4 decreased corneal MMP-2 and -9 and MT6-MMP levels after alkali injury, no change in TIMP-1 and -2 expression was detected.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with corneal alkali injury, topical Tbeta4 did not change TIMP-2 expression compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 did not change TIMP-2 in the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCorneal TIMP-2 expression
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Whereas Tbeta4 decreased corneal MMP-2 and -9 and MT6-MMP levels after alkali injury, no change in TIMP-1 and -2 expression was detected.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with corneal alkali injury, topical Tbeta4 decreased corneal KC (CXCL1) chemokine expression compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 lowered the inflammation signal KC in the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCorneal KC (CXCL1) chemokine expression
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Tbeta4 treatment also decreased corneal KC (CXCL1) and macrophage inflammatory protein (MIP)-2 chemokine expression and PMN infiltration.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with corneal alkali injury, topical Tbeta4 decreased corneal MIP-2 chemokine expression compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 lowered the inflammation signal MIP-2 in the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCorneal MIP-2 chemokine expression
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Tbeta4 treatment also decreased corneal KC (CXCL1) and macrophage inflammatory protein (MIP)-2 chemokine expression and PMN infiltration.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with corneal alkali injury, topical Tbeta4 decreased polymorphonuclear cell infiltration of the cornea compared with PBS.

    In plain wordsIn mice with a corneal alkali burn, Tbeta4 reduced the number of inflammatory white cells entering the cornea compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCorneal PMN infiltration
    Study

    mousen: not reported in source

    BALB/c mice with corneal NaOH alkali injury
    Comparator
    PBS
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Tbeta4 treatment also decreased corneal KC (CXCL1) and macrophage inflammatory protein (MIP)-2 chemokine expression and PMN infiltration.
    2 context sentences
    Summary · context
    Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either Tbeta4 or PBS twice daily.
    Summary · context
    At various time points after injury (PI), corneas from the Tbeta4- versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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