A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists.

Kolibianakis EM, Schultze-Mosgau A, Schroer A, van Steirteghem A, Devroey P, Diedrich K, Griesinger G

Human reproduction (Oxford, England)24 Jun 2005Cited by 230 (Europe PMC)

PMID15979994DOI10.1093/humrep/dei150PepBankPUB-15979994

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialEfficacy outcome
In IVF patients, triptorelin and HCG triggers produced no significant difference in retrieved cumulus-oocyte complexes.
In plain wordsIn IVF patients, triptorelin and HCG triggers produced similar numbers of retrieved cumulus-oocyte complexes.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeRetrieved cumulus-oocyte complexes
Study
n = 106
Comparator
Urinary HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Source sentences
Summary
No significant differences were present in the number of cumulus-oocyte complexes retrieved, in the proportion of metaphase II oocytes, in fertilization rates or in the number and quality of the embryos transferred between the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
106 patients were randomized to receive either 10 000 IU urinary HCG or 0.2 mg Triptorelin for triggering final oocyte maturation.
Summary · context
Ovarian stimulation for IVF was performed with a fixed dose of 200 IU recombinant FSH and GnRH antagonist was started on stimulation day 6.
Summary · context
Luteal phase was supported with micronized vaginal progesterone and oral estradiol.
Report a problemFND-1597999401
02HumanRandomized controlled trialEfficacy outcome
In IVF patients, triptorelin and HCG triggers produced no significant difference in the proportion of metaphase II oocytes.
In plain wordsIn IVF patients, triptorelin and HCG triggers produced similar proportions of mature oocytes.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeMetaphase II oocyte proportion
Study
n = 106
Comparator
Urinary HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Source sentences
Summary
No significant differences were present in the number of cumulus-oocyte complexes retrieved, in the proportion of metaphase II oocytes, in fertilization rates or in the number and quality of the embryos transferred between the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
106 patients were randomized to receive either 10 000 IU urinary HCG or 0.2 mg Triptorelin for triggering final oocyte maturation.
Summary · context
Ovarian stimulation for IVF was performed with a fixed dose of 200 IU recombinant FSH and GnRH antagonist was started on stimulation day 6.
Summary · context
Luteal phase was supported with micronized vaginal progesterone and oral estradiol.
Report a problemFND-1597999402
03HumanRandomized controlled trialEfficacy outcome
In IVF patients, triptorelin and HCG triggers produced no significant difference in fertilization rates.
In plain wordsIn IVF patients, triptorelin and HCG triggers produced similar fertilization rates.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFertilization rate
Study
n = 106
Comparator
Urinary HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Source sentences
Summary
No significant differences were present in the number of cumulus-oocyte complexes retrieved, in the proportion of metaphase II oocytes, in fertilization rates or in the number and quality of the embryos transferred between the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
106 patients were randomized to receive either 10 000 IU urinary HCG or 0.2 mg Triptorelin for triggering final oocyte maturation.
Summary · context
Ovarian stimulation for IVF was performed with a fixed dose of 200 IU recombinant FSH and GnRH antagonist was started on stimulation day 6.
Summary · context
Luteal phase was supported with micronized vaginal progesterone and oral estradiol.
Report a problemFND-1597999403
04HumanRandomized controlled trialEfficacy outcome
In IVF patients, triptorelin and HCG triggers produced no significant difference in the number of transferred embryos.
In plain wordsIn IVF patients, triptorelin and HCG triggers produced similar numbers of transferred embryos.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeNumber of transferred embryos
Study
n = 106
Comparator
Urinary HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Source sentences
Summary
No significant differences were present in the number of cumulus-oocyte complexes retrieved, in the proportion of metaphase II oocytes, in fertilization rates or in the number and quality of the embryos transferred between the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
106 patients were randomized to receive either 10 000 IU urinary HCG or 0.2 mg Triptorelin for triggering final oocyte maturation.
Summary · context
Ovarian stimulation for IVF was performed with a fixed dose of 200 IU recombinant FSH and GnRH antagonist was started on stimulation day 6.
Summary · context
Luteal phase was supported with micronized vaginal progesterone and oral estradiol.
Report a problemFND-1597999404
05HumanRandomized controlled trialEfficacy outcome
In IVF patients, triptorelin and HCG triggers produced no significant difference in transferred embryo quality.
In plain wordsIn IVF patients, triptorelin and HCG triggers produced similar transferred embryo quality.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeQuality of transferred embryos
Study
n = 106
Comparator
Urinary HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Source sentences
Summary
No significant differences were present in the number of cumulus-oocyte complexes retrieved, in the proportion of metaphase II oocytes, in fertilization rates or in the number and quality of the embryos transferred between the two groups.
3 context sentences(design, population, supporting numbers)
Summary · context
106 patients were randomized to receive either 10 000 IU urinary HCG or 0.2 mg Triptorelin for triggering final oocyte maturation.
Summary · context
Ovarian stimulation for IVF was performed with a fixed dose of 200 IU recombinant FSH and GnRH antagonist was started on stimulation day 6.
Summary · context
Luteal phase was supported with micronized vaginal progesterone and oral estradiol.
Report a problemFND-1597999405
06HumanRandomized controlled trialEfficacy outcome
In IVF patients, triptorelin triggering reduced ongoing pregnancy probability versus HCG, which prompted early trial discontinuation.
In plain wordsIn IVF patients, triptorelin reduced ongoing pregnancy probability versus HCG, which prompted early trial discontinuation.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOngoing pregnancy probability
Study
n = 106
Comparator
Urinary HCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mgAs given in this study (human).
Measurements
Odds ratio
0.11 ratio
ongoing pregnancy versus HCG
95% confidence interval
0.02 to 0.52 ratio
ongoing pregnancy odds ratio
Source sentences
Summary
However, a significantly lower probability of ongoing pregnancy in the GnRH agonist arm prompted discontinuation of the trial, according to the stopping rules established (odds ratio 0.11; 95% confidence interval 0.02-0.52).
3 context sentences(design, population, supporting numbers)
Summary · context
106 patients were randomized to receive either 10 000 IU urinary HCG or 0.2 mg Triptorelin for triggering final oocyte maturation.
Summary · context
Ovarian stimulation for IVF was performed with a fixed dose of 200 IU recombinant FSH and GnRH antagonist was started on stimulation day 6.
Summary · context
Luteal phase was supported with micronized vaginal progesterone and oral estradiol.
Report a problemFND-1597999406