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Study · In vitro (cell-free) · 2005

1 result

Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor.

Johansson S, Fredholm BB, Hjort C, Morein T, Kull B, Hu PS

Biochemical pharmacology1 Aug 2005Cited by 11 (Europe PMC)

PMID15979585 (opens in a new tab)DOI10.1016/j.bcp.2005.05.023 (opens in a new tab)PepBankPUB-15979585
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In CHO cell membrane binding assays, MK-0677 displaced radiolabeled ghrelin binding with an IC50 of 0.34 nM.

    In plain wordsIn lab tests, MK-0677 displaced labeled ghrelin from receptor binding sites.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableGhrelin binding displacement IC50
    Study

    n: not reported in source

    GHSR1a-transfected CHO cell membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    IC50
    0.34 nM
    MK-0677

    Source sentences

    Summary
    In binding studies on GHSR1a transfected CHO cell membranes, [(125)I]-hGhrelin binding could be displaced by the GHSR1a agonist MK-0677 (IC50: 0.34 nM)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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