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Study · Animal study (in vivo) · rat · 2005

7 results

Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition.

Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M

Endocrinology2 Jun 2005Cited by 400 (Europe PMC)

PMID15932928 (opens in a new tab)DOI10.1210/en.2005-0337 (opens in a new tab)PepBankPUB-15932928
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In fasted prepubertal rats, the in vivo LH response to kisspeptin was enhanced.

    In plain wordsIn fasted young rats, kisspeptin raised LH more strongly.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH response to kisspeptin under fasting
    Study

    ratn: not reported in source

    prepubertal rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, LH responses to kisspeptin in vivo were enhanced, and its GnRH secretagogue action in vitro was sensitized, under fasting conditions.
    1 context sentence
    Summary · context
    In this work, we evaluated the expression of KiSS-1 and GPR54 genes at the hypothalamus as well as the ability of kisspeptin-10 to elicit GnRH and LH secretion in prepubertal rats under short-term fasting.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal rats fed ad libitum or fasted for 12 h, central kisspeptin did not change food intake patterns.

    In plain wordsIn young rats, kisspeptin given into the brain did not change how much they ate.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeFood intake after central kisspeptin
    Study

    ratn: not reported in source

    prepubertal rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · centralAs given in this study (rat).

    Source sentences

    Summary
    Central kisspeptin administration failed to change food intake patterns in animals fed ad libitum or after a 12-h fast.
    1 context sentence
    Summary · context
    In this work, we evaluated the expression of KiSS-1 and GPR54 genes at the hypothalamus as well as the ability of kisspeptin-10 to elicit GnRH and LH secretion in prepubertal rats under short-term fasting.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In an undernutrition model in rats, chronic kisspeptin restored vaginal opening in approximately 60% of animals.

    In plain wordsIn underfed young rats, long-term kisspeptin restored puberty onset, shown by vaginal opening, in about 60% of animals.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseVaginal opening with chronic kisspeptin in undernutrition
    Study

    ratn: not reported in source

    prepubertal rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    vaginal opening restored
    ≈ 60%
    undernourished rats given chronic kisspeptin

    Source sentences

    Summary
    However, chronic treatment with kisspeptin was able to restore vaginal opening (in approximately 60%) and to elicit gonadotropin and estrogen responses in a model of undernutrition.
    2 context sentences
    Summary · context
    In addition, we monitored the actions of kisspeptin on food intake and the effects of its chronic administration upon puberty onset in undernutrition.
    Summary · context
    In this work, we evaluated the expression of KiSS-1 and GPR54 genes at the hypothalamus as well as the ability of kisspeptin-10 to elicit GnRH and LH secretion in prepubertal rats under short-term fasting.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In an undernutrition model in rats, chronic kisspeptin elicited gonadotropin responses.

    In plain wordsIn underfed young rats, long-term kisspeptin raised gonadotropin hormones.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGonadotropin response with chronic kisspeptin in undernutrition
    Study

    ratn: not reported in source

    prepubertal rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, chronic treatment with kisspeptin was able to restore vaginal opening (in approximately 60%) and to elicit gonadotropin and estrogen responses in a model of undernutrition.
    2 context sentences
    Summary · context
    In addition, we monitored the actions of kisspeptin on food intake and the effects of its chronic administration upon puberty onset in undernutrition.
    Summary · context
    In this work, we evaluated the expression of KiSS-1 and GPR54 genes at the hypothalamus as well as the ability of kisspeptin-10 to elicit GnRH and LH secretion in prepubertal rats under short-term fasting.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In an undernutrition model in rats, chronic kisspeptin elicited estrogen responses.

    In plain wordsIn underfed young rats, long-term kisspeptin raised estrogen.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseEstrogen response with chronic kisspeptin in undernutrition
    Study

    ratn: not reported in source

    prepubertal rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, chronic treatment with kisspeptin was able to restore vaginal opening (in approximately 60%) and to elicit gonadotropin and estrogen responses in a model of undernutrition.
    2 context sentences
    Summary · context
    In addition, we monitored the actions of kisspeptin on food intake and the effects of its chronic administration upon puberty onset in undernutrition.
    Summary · context
    In this work, we evaluated the expression of KiSS-1 and GPR54 genes at the hypothalamus as well as the ability of kisspeptin-10 to elicit GnRH and LH secretion in prepubertal rats under short-term fasting.
  6. 06LabEx vivo tissueEfficacy outcome

    In hypothalamic tissue from fasted prepubertal rats, the GnRH-releasing action of kisspeptin in vitro was sensitized.

    In plain wordsIn lab tests on brain tissue from fasted young rats, kisspeptin triggered GnRH release more readily.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGnRH secretagogue action of kisspeptin in vitro under fasting
    Study

    ratn: not reported in source

    prepubertal rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, LH responses to kisspeptin in vivo were enhanced, and its GnRH secretagogue action in vitro was sensitized, under fasting conditions.
    1 context sentence
    Summary · context
    In this work, we evaluated the expression of KiSS-1 and GPR54 genes at the hypothalamus as well as the ability of kisspeptin-10 to elicit GnRH and LH secretion in prepubertal rats under short-term fasting.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 07AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In prepubertal rats, food deprivation decreased hypothalamic KiSS-1 mRNA, the gene of the body's own kisspeptin.

    In plain wordsIn rats, fasting lowered the activity of the gene for the body's own kisspeptin in the brain.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHypothalamic KiSS-1 mRNA under food deprivation
    Study

    ratn: not reported in source

    prepubertal rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Food deprivation induced a concomitant decrease in hypothalamic KiSS-1 and increase in GPR54 mRNA levels in prepubertal rats.
    1 context sentence
    Summary · context
    In this work, we evaluated the expression of KiSS-1 and GPR54 genes at the hypothalamus as well as the ability of kisspeptin-10 to elicit GnRH and LH secretion in prepubertal rats under short-term fasting.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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