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Study · Ex vivo tissue · rat · 2006

6 results

Liver parenchyma heterogeneity in the response to extracellular NAD+.

Gimenes D, Constantin J, Comar JF, Kelmer-Bracht AM, Broetto-Biazon AC, Bracht A

Cell biochemistry and function1 Jul 2006Cited by 8 (Europe PMC)

PMID15920702 (opens in a new tab)DOI10.1002/cbf.1228 (opens in a new tab)PepBankPUB-15920702
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In perfused rat liver, NAD+ stimulated oxygen uptake during retrograde perfusion irrespective of infusion route.

    In plain wordsIn lab tests with rat liver, NAD+ increased oxygen uptake during retrograde perfusion.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseOxygen uptake during retrograde perfusion
    Study

    ratn: not reported in source

    Bivascularly perfused liver
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxygen uptake was stimulated by NAD+ in retrograde perfusion (irrespective of the infusion route) and transiently inhibited in antegrade perfusion.
    1 context sentence
    Summary · context
    The bivascularly perfused rat liver was used.
  2. 02LabEx vivo tissueMechanism

    In perfused rat liver, NAD+ transiently inhibited oxygen uptake during antegrade perfusion.

    In plain wordsIn lab tests with rat liver, NAD+ temporarily reduced oxygen uptake during antegrade perfusion.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseOxygen uptake during antegrade perfusion
    Study

    ratn: not reported in source

    Bivascularly perfused liver
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxygen uptake was stimulated by NAD+ in retrograde perfusion (irrespective of the infusion route) and transiently inhibited in antegrade perfusion.
    1 context sentence
    Summary · context
    The bivascularly perfused rat liver was used.
  3. 03LabEx vivo tissueMechanism

    In perfused rat liver, the results indicated that the NAD+-associated oxygen uptake inhibition signal originated in the periportal area.

    In plain wordsIn lab tests with rat liver, results indicated that the NAD+-associated oxygen inhibition signal originated in the periportal area.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableRegional oxygen uptake inhibition signal
    Study

    ratn: not reported in source

    Bivascularly perfused liver
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This indicates that the signal causing oxygen uptake inhibition is generated in the periportal area.
    2 context sentences
    Summary · context
    Oxygen uptake was stimulated by NAD+ in retrograde perfusion (irrespective of the infusion route) and transiently inhibited in antegrade perfusion.
    Summary · context
    The bivascularly perfused rat liver was used.
  4. 04LabEx vivo tissueMechanism

    In perfused rat liver, the NAD+-associated oxygen uptake stimulation signal was homogeneously distributed.

    In plain wordsIn lab tests with rat liver, the NAD+-associated oxygen stimulation signal was evenly distributed.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableRegional oxygen uptake stimulation signal
    Study

    ratn: not reported in source

    Bivascularly perfused liver
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The signal responsible for oxygen uptake stimulation is homogenously distributed.
    2 context sentences
    Summary · context
    Oxygen uptake was stimulated by NAD+ in retrograde perfusion (irrespective of the infusion route) and transiently inhibited in antegrade perfusion.
    Summary · context
    The bivascularly perfused rat liver was used.
  5. 05LabEx vivo tissueMechanism

    In perfused rat liver, NAD+ stimulated glucose release more intensely with portal vein or hepatic artery infusion than with hepatic vein infusion.

    In plain wordsIn lab tests with rat liver, NAD+ stimulated glucose release more through the portal vein or hepatic artery than the hepatic vein.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseGlucose release by infusion region
    Study

    ratn: not reported in source

    Bivascularly perfused liver
    Comparator
    Hepatic vein infusion
    Outcome group
    Glycemic control · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Stimulation of glucose release was more intense when NAD+ was infused into the portal vein or into the hepatic artery, indicating that stimulation of glycogenolysis predominates in the periportal area.
    2 context sentences
    Summary · context
    The bivascularly perfused rat liver was used.
    Summary · context
    Various combinations of perfusion directions (antegrade and retrograde) and infusion routes (portal vein, hepatic vein and hepatic artery) were used in order to supply NAD+ to different regions of the liver parenchyma, also taking advantage of the fact that its extracellular transformation generates…
  6. 06LabEx vivo tissueMechanism

    In perfused rat liver, NAD+ increased perfusion pressure more when supplied to the periportal area.

    In plain wordsIn lab tests with rat liver, NAD+ increased perfusion pressure more when supplied to the periportal area.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreasePerfusion pressure by infusion region
    Study

    ratn: not reported in source

    Bivascularly perfused liver
    Outcome group
    Blood pressure · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The increases in perfusion pressure were more pronounced when the periportal area was supplied with NAD+ suggesting that the vasoconstrictive elements responding to NAD+ predominate in this region.
    1 context sentence
    Summary · context
    The bivascularly perfused rat liver was used.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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