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Study · In vitro (cells) · rat · 2005

2 results

Humanin attenuates apoptosis induced by DRPLA proteins with expanded polyglutamine stretches.

Kariya S, Hirano M, Nagai Y, Furiya Y, Fujikake N, Toda T, Ueno S

Journal of molecular neuroscience : MN1 Jan 2005Cited by 29 (Europe PMC)

PMID15784964 (opens in a new tab)DOI10.1385/jmn:25:2:165 (opens in a new tab)PepBankPUB-15784964
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In PC12 cells expressing expanded polyglutamine stretches, humanin suppressed apoptotic cell death, but the suppression was incomplete.

    In plain wordsIn rat nerve-like cells with a disease protein, humanin reduced cell death, but only in part.

    Peptide
    Humanin
    Outcome
    DecreaseApoptotic cell death induced by expanded polyQs
    Study

    ratn: not reported in source

    PC12 cells expressing expanded polyQs (Tet-Off)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    we showed that HN suppresses apoptotic cell death induced by expanded polyQs.
    2 context sentences
    Summary · context
    However, the suppression was incomplete, suggesting that polyQs also stimulate other pathogenic cascades unrelated to ASK1.
    Summary · context
    To test the anti-ASK1 effect of HN on polyQ neurotoxicity, we constructed neuronal PC12 cells expressing expanded polyQs under the control of the Tet-Off system.
  2. 02LabIn vitro (cells)Mechanism

    In PC12 cells expressing expanded polyglutamine stretches, humanin suppressed polyQ aggregate formation.

    In plain wordsIn rat nerve-like cells with a disease protein, humanin reduced the clumping of that protein.

    Peptide
    Humanin
    Outcome
    DecreasePolyQ aggregate formation
    Study

    ratn: not reported in source

    PC12 cells expressing expanded polyQs (Tet-Off)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further showed that HN suppresses polyQ aggregate formation.
    1 context sentence
    Summary · context
    To test the anti-ASK1 effect of HN on polyQ neurotoxicity, we constructed neuronal PC12 cells expressing expanded polyQs under the control of the Tet-Off system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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