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Study · In vitro (cells) · 2005

5 results

Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent.

Kariya S, Hirano M, Furiya Y, Sugie K, Ueno S

Acta neuropathologica10 Mar 2005Cited by 40 (Europe PMC)

PMID15759134 (opens in a new tab)DOI10.1007/s00401-004-0965-5 (opens in a new tab)PepBankPUB-15759134
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In muscular TE671 cells, synthesized humanin may increase cellular ATP levels by acting directly on mitochondria.

    In plain wordsIn lab muscle cells, humanin may raise ATP levels by acting directly on mitochondria.

    Peptide
    Humanin
    Outcome
    IncreaseCellular ATP level in TE671 cells
    Study

    humann: not reported in source

    muscular TE671 cells
    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our experiments on muscular TE671 cells indicated the possibility that synthesized HN increases cellular ATP levels by directly acting on mitochondria.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02HumanEndogenous levelObservational studyOther

    In skeletal muscle from patients with MELAS, expression of the body's own humanin was increased.

    In plain wordsIn muscle from people with MELAS, the body's own humanin was higher.

    Peptide
    Humanin
    Outcome
    IncreaseHN expression in skeletal muscle of MELAS patients
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    Here, we report, for the first time, increased HN expression in skeletal muscles from patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 03HumanEndogenous levelObservational studyOther

    In MELAS muscle, humanin was strongly positive in all ragged-red fibers and some non-ragged-red fibers, mostly type 1 fibers.

    In plain wordsIn MELAS muscle, natural humanin was found strongly in damaged fibers, mostly the type that needs more energy.

    Peptide
    Humanin
    Outcome
    IncreaseHN staining in ragged-red fibers
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    HN was strongly positive in all ragged-red fibers (RRFs) and some non-RRFs, and most of them were type 1 fibers generally requiring higher energy than type 2 fibers.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 04HumanEndogenous levelObservational studyMechanism

    In MELAS muscle fibers, humanin was localized in mitochondria.

    In plain wordsIn MELAS muscle, natural humanin was found inside mitochondria, the cell's energy units.

    Peptide
    Humanin
    Outcome
    Not applicableSubcellular location of HN in MELAS muscle fibers
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    HN in these fibers was localized in mitochondria.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 05HumanEndogenous levelObservational studyOther

    In MELAS muscle, humanin expression was also increased in small arteries that reacted strongly for succinate dehydrogenase.

    In plain wordsIn MELAS muscle, natural humanin was also higher in small blood vessels.

    Peptide
    Humanin
    Outcome
    IncreaseHN expression in small arteries
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Cardiovascular

    Source sentences

    Summary
    HN expression was also increased in small arteries that strongly reacted for succinate dehydrogenase.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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