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Study · Not a test of the peptide alone · 2005

3 results

Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.

Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M

Biochemical and biophysical research communications1 Apr 2005Cited by 45 (Europe PMC)

PMID15721287 (opens in a new tab)DOI10.1016/j.bbrc.2005.01.100 (opens in a new tab)PepBankPUB-15721287
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cell-free)Other

    In aqueous solution, synthetic humanin was predominantly unstructured, in equilibrium with turn-like structures involving residues Gly5 to Leu10 and Glu15 to Leu18.

    In plain wordsIn lab tests in water, humanin was mostly a loose chain with some turn-like shapes.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin conformation in aqueous solution
    Study

    n: not reported in source

    synthetic humanin in aqueous and 30% TFE solutions
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In aqueous solution, humanin exists predominantly in an unstructured conformation in equilibrium with turn-like structures involving residues Gly5 to Leu10 and Glu15 to Leu18, providing indication of nascent helix.
    1 context sentence
    Summary · context
    In this study, NMR and circular dichroism studies of synthetic humanin in aqueous and 30% 2,2,2-trifluoroethanol (TFE) solutions are reported.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cell-free)Other

    In 30% TFE, synthetic humanin readily adopted helical structure with long-range order spanning residues Gly5 to Leu18.

    In plain wordsIn lab tests in a less polar liquid, humanin formed a helix shape.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin conformation in 30% TFE
    Study

    n: not reported in source

    synthetic humanin in aqueous and 30% TFE solutions
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In the less polar environment of 30% TFE, humanin readily adopts helical structure with long-range order spanning residues Gly5 to Leu18.
    1 context sentence
    Summary · context
    In this study, NMR and circular dichroism studies of synthetic humanin in aqueous and 30% 2,2,2-trifluoroethanol (TFE) solutions are reported.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03Computer modelNot a test of Humanin aloneIn silicoOther

    Comparative 3D modeling and topology predictions agreed qualitatively with the experimental findings in both environments.

    In plain wordsComputer models of humanin gave shapes that matched the lab measurements in both liquids.

    Peptide
    Humanin
    Outcome
    Not applicablePredicted humanin structure versus NMR findings
    Study

    n: not reported in source

    comparative 3D modeling and topology prediction
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Comparative 3D modeling studies and topology predictions are in qualitative agreement with the experimental findings in both environments.
    1 context sentence
    Summary · context
    In this study, NMR and circular dichroism studies of synthetic humanin in aqueous and 30% 2,2,2-trifluoroethanol (TFE) solutions are reported.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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