[Expression of thymosin beta 4 mRNA expression in keloid tissues and fibroblasts cultured from keloid and its significance].

Nie FF, Wu JQ, Qin ZL

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue1 Feb 2005Cited by 1 (Europe PMC)

PMID15698487PepBankPUB-15698487

Publisher pageAsk about this study

Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyMechanism
In patients, thymosin beta‑4 mRNA levels were lower in keloid tissue than in hypertrophic scar tissue (P<0.01).
In plain wordsIn patients, the body's own thymosin beta‑4 mRNA was lower in keloid tissue than in hypertrophic scar tissue.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseThymosin beta 4 mRNA in keloid versus hypertrophic scar tissue
Study
n: not reported in source
Comparator
Hypertrophic scar tissue
Outcome group
Wound healing · Skin and wound
Measurements
mRNA level difference, lower in keloid
66.98%
keloid vs hypertrophic scar tissue
Source sentences
Summary
The mRNA levels of thymosin beta 4 in the keloid tissues were lower than those in the tissues of hypertrophic scar and normal skin(both, P<0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
The thymosin beta 4 mRNA level in keloid group was lower by 66.98% than hypertrophic scar
Summary · context
The primary fibroblasts from the patients of keloid (KFB), hypertrophic scar (HFB) and normal skin (NFB, n=7) were cultured in vitro with tissue culture system.
Summary · context
Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay was used to assess the thymosin beta 4 mRNA levels in the tissues and fibroblasts obtained from the patients of three groups.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1569848701
02HumanEndogenous levelObservational studyMechanism
In patients, thymosin beta‑4 mRNA levels were lower in keloid tissue than in normal skin (P<0.01).
In plain wordsIn patients, the body's own thymosin beta‑4 mRNA was lower in keloid tissue than in normal skin.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseThymosin beta 4 mRNA in keloid versus normal skin tissue
Study
n: not reported in source
Comparator
Normal skin
Outcome group
Wound healing · Skin and wound
Measurements
mRNA level difference, lower in keloid
62.48%
keloid vs normal skin
Source sentences
Summary
The mRNA levels of thymosin beta 4 in the keloid tissues were lower than those in the tissues of hypertrophic scar and normal skin(both, P<0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
62.48% than normal skin.
Summary · context
The primary fibroblasts from the patients of keloid (KFB), hypertrophic scar (HFB) and normal skin (NFB, n=7) were cultured in vitro with tissue culture system.
Summary · context
Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay was used to assess the thymosin beta 4 mRNA levels in the tissues and fibroblasts obtained from the patients of three groups.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1569848702
03LabEndogenous levelIn vitro (cells)Mechanism
In cultured fibroblasts, thymosin beta‑4 mRNA was lower in keloid fibroblasts than in hypertrophic scar fibroblasts.
In plain wordsIn cells, the body's own thymosin beta‑4 mRNA was lower in keloid fibroblasts than in hypertrophic scar fibroblasts.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseThymosin beta 4 mRNA in cultured keloid versus hypertrophic scar fibroblasts
Study
humann: not reported in source
primary fibroblasts cultured from keloid, hypertrophic scar and normal skin
Comparator
Hypertrophic scar fibroblasts
Outcome group
Wound healing · Skin and wound
Measurements
mRNA level difference, lower in KFB
27.13%
KFB vs HFB
Source sentences
Summary
In addition, the same significant change was found in the cultured KFB compared with HFB group(the mean value was lower by 27.13%), but no difference was found between KFB and NFB.
2 context sentences(design, population, supporting numbers)
Summary · context
The primary fibroblasts from the patients of keloid (KFB), hypertrophic scar (HFB) and normal skin (NFB, n=7) were cultured in vitro with tissue culture system.
Summary · context
Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay was used to assess the thymosin beta 4 mRNA levels in the tissues and fibroblasts obtained from the patients of three groups.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1569848703
04LabEndogenous levelIn vitro (cells)Mechanism
In cultured fibroblasts, thymosin beta‑4 mRNA did not differ between keloid fibroblasts and normal skin fibroblasts.
In plain wordsIn cells, the body's own thymosin beta‑4 mRNA did not differ between keloid fibroblasts and normal skin fibroblasts.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeThymosin beta 4 mRNA in cultured keloid versus normal skin fibroblasts
Study
humann: not reported in source
primary fibroblasts cultured from keloid, hypertrophic scar and normal skin
Comparator
Normal skin fibroblasts
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
but no difference was found between KFB and NFB.
2 context sentences(design, population, supporting numbers)
Summary · context
The primary fibroblasts from the patients of keloid (KFB), hypertrophic scar (HFB) and normal skin (NFB, n=7) were cultured in vitro with tissue culture system.
Summary · context
Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay was used to assess the thymosin beta 4 mRNA levels in the tissues and fibroblasts obtained from the patients of three groups.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1569848704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.