Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates.

Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM

Proceedings of the National Academy of Sciences of the United States of America31 Jan 2005Cited by 627 (Europe PMC)

PMID15684075PMCIDPMC548549DOI10.1073/pnas.0409822102PepBankPUB-15684075

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In juvenile male monkeys, intracerebroventricular kisspeptin‑10 elicited a robust GnRH discharge, reflected by LH secretion.
In plain wordsIn monkeys, kisspeptin‑10 given into the brain triggered a strong GnRH release, shown by a rise in LH.
Peptide
Kisspeptin-10
Outcome
IncreaseLH/GnRH discharge after intracerebroventricular kisspeptin-10
Study
monkeyn: not reported in source
agonadal juvenile male monkeys primed with pulsatile GnRH
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
30 microg or 100 microg · intracerebroventricularAs given in this study (monkey).
Source sentences
Summary
Intracerebroventricular (30 microg or 100 microg) or i.v. (100 microg) bolus injections of kisspeptin-10 elicited a robust GnRH discharge, as reflected by luteinizing hormone secretion
1 context sentence(design, population, supporting numbers)
Summary · context
To further study the role of GPR54 signaling in the onset of primate puberty, we used the monkey to examine the ability of kisspeptin-10 to elicit the release of gonadotropin-releasing hormone (GnRH) precociously, and we describe the expression of GPR54 and KiSS-1 in the hypothalamus during the peripubertal period.
Report a problemFND-1568407501
02AnimalAnimal study (in vivo)Efficacy outcome
In juvenile male monkeys, an intravenous kisspeptin‑10 bolus elicited a robust GnRH discharge, reflected by LH secretion.
In plain wordsIn monkeys, kisspeptin‑10 given into a vein triggered a strong GnRH release, shown by a rise in LH.
Peptide
Kisspeptin-10
Outcome
IncreaseLH/GnRH discharge after intravenous kisspeptin-10
Study
monkeyn: not reported in source
agonadal juvenile male monkeys primed with pulsatile GnRH
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 microg · intravenousAs given in this study (monkey).
Source sentences
Summary
Intracerebroventricular (30 microg or 100 microg) or i.v. (100 microg) bolus injections of kisspeptin-10 elicited a robust GnRH discharge, as reflected by luteinizing hormone secretion
1 context sentence(design, population, supporting numbers)
Summary · context
To further study the role of GPR54 signaling in the onset of primate puberty, we used the monkey to examine the ability of kisspeptin-10 to elicit the release of gonadotropin-releasing hormone (GnRH) precociously, and we describe the expression of GPR54 and KiSS-1 in the hypothalamus during the peripubertal period.
Report a problemFND-1568407502

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In male and female monkeys, hypothalamic KiSS-1 mRNA, the gene of the body's own kisspeptin, increased with puberty.
In plain wordsIn monkeys, activity of the gene for the body's own kisspeptin in the brain rose with puberty.
Peptide
Kisspeptin-10
Outcome
IncreaseHypothalamic KiSS-1 mRNA with puberty
Study
monkeyn: not reported in source
hypothalamus of male and female monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
KiSS-1 mRNA levels detected by real-time PCR increased with puberty in both male and female monkeys.
1 context sentence(design, population, supporting numbers)
Summary · context
RNA was isolated from the hypothalamus of agonadal males before (juvenile) and after (pubertal) the pubertal resurgence of pulsatile GnRH release and from juvenile, early pubertal, and midpubertal ovary-intact females.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1568407504
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In monkeys, hybridization histochemistry showed robust KiSS-1 mRNA expression in the region of the arcuate nucleus.
In plain wordsIn monkeys, the gene for the body's own kisspeptin was strongly active in a brain area called the arcuate nucleus.
Peptide
Kisspeptin-10
Outcome
Not applicableKiSS-1 mRNA expression in the arcuate nucleus
Study
monkeyn: not reported in source
monkey hypothalamus
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Hybridization histochemistry indicated robust KiSS-1 and GPR54 mRNA expression in the region of the arcuate nucleus.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1568407505

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In juvenile male monkeys, pretreatment with a GnRH-receptor antagonist abolished the LH response to kisspeptin‑10.
In plain wordsIn monkeys, blocking the GnRH receptor removed the LH response to kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
DecreaseEffect of GnRH-receptor antagonist on kisspeptin-10-induced LH
Study
monkeyn: not reported in source
agonadal juvenile male monkeys primed with pulsatile GnRH
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
which was abolished by pretreatment with a GnRH-receptor antagonist.
1 context sentence(design, population, supporting numbers)
Summary · context
To further study the role of GPR54 signaling in the onset of primate puberty, we used the monkey to examine the ability of kisspeptin-10 to elicit the release of gonadotropin-releasing hormone (GnRH) precociously, and we describe the expression of GPR54 and KiSS-1 in the hypothalamus during the peripubertal period.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-1568407503

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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