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Study · Animal study (in vivo) · mouse · 2005

5 results

A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice.

Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I

Journal of neuroscience research1 Mar 2005Cited by 88 (Europe PMC)

PMID15678515 (opens in a new tab)DOI10.1002/jnr.20391 (opens in a new tab)PepBankPUB-15678515
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with amyloid-beta-induced amnesia, S14G-HN (at least 50 pmol, intracerebroventricular) prevented impairment of short-term/spatial working memory in the Y-maze.

    In plain wordsIn mice with induced memory loss, S14G-HN prevented a drop in short-term memory in a maze test.

    Peptide
    Humanin
    Outcome
    IncreaseY-maze short-term/spatial working memory
    Study

    mousen: not reported in source

    Abeta25-35-induced amnesia
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    at least 50 pmol · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    The Y-maze test revealed that at least 50 pmol of S14G-HN by intracerebroventricular injection prevented Abeta-induced impairment of short-term/spatial working memory
    1 context sentence
    Summary · context
    We examined the effect of S14G-HN, a 1,000-fold more potent derivative of HN in vitro, on amnesia induced by Abeta25-35 in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In amyloid-beta-amnesic mice, S14G-HN prevented the prolongation of water-finding latency, so it blocked impairment of latent learning.

    In plain wordsIn mice with induced memory loss, S14G-HN prevented the slower water finding that the memory loss caused.

    Peptide
    Humanin
    Outcome
    DecreaseWater-finding latency (latent learning)
    Study

    mousen: not reported in source

    Abeta25-35-induced amnesia
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the water-finding task, S14G-HN prevented prolongation of finding latency (the time to find water) observed in Abeta-amnesic mice, indicating that S14G-HN also blocked Abeta-induced impairment of latent learning.
    1 context sentence
    Summary · context
    We examined the effect of S14G-HN, a 1,000-fold more potent derivative of HN in vitro, on amnesia induced by Abeta25-35 in mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In amyloid-beta-amnesic mice, S14G-HN sustained the number of cholinergic neurons in the basal forebrain and striata nearly to the normal level.

    In plain wordsIn mice with induced memory loss, S14G-HN kept the number of certain brain nerve cells close to normal.

    Peptide
    Humanin
    Outcome
    IncreaseCholinergic neurons in basal forebrain and striata
    Study

    mousen: not reported in source

    Abeta25-35-induced amnesia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In accordance with these observations, immunohistochemical analysis showed that S14G-HN sustained the number of cholinergic neurons in the basal forebrain and the striata nearly to the normal level.
    1 context sentence
    Summary · context
    We examined the effect of S14G-HN, a 1,000-fold more potent derivative of HN in vitro, on amnesia induced by Abeta25-35 in mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with scopolamine-induced amnesia, the tyrosine kinase inhibitor genistein blocked the recovery that S14G-HN produced.

    In plain wordsIn mice with induced memory loss, a drug that blocks tyrosine kinases stopped the memory recovery caused by S14G-HN.

    Peptide
    Humanin
    Outcome
    Not applicableGenistein block of S14G-HN recovery from scopolamine-induced amnesia
    Study

    mousen: not reported in source

    scopolamine-induced amnesia
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    genistein, a specific inhibitor of tyrosine kinases, blocked recovery from scopolamine-induced amnesia by S14G-HN
    1 context sentence
    Summary · context
    We examined the effect of S14G-HN, a 1,000-fold more potent derivative of HN in vitro, on amnesia induced by Abeta25-35 in mice.

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 05AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice with amyloid-beta-induced amnesia, 5 nmol of the S14A-HN mutant did not prevent Abeta-induced amnesia.

    In plain wordsIn mice with induced memory loss, a changed, inactive version of the peptide did not prevent the memory loss.

    Peptide
    Humanin
    Outcome
    No significant changeY-maze memory with S14A-HN mutant
    Study

    mousen: not reported in source

    Abeta25-35-induced amnesia
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    5 nmol of S14A-HN, a neuroprotection-defective mutant in vitro, did not prevent Abeta-induced amnesia.
    1 context sentence
    Summary · context
    We examined the effect of S14G-HN, a 1,000-fold more potent derivative of HN in vitro, on amnesia induced by Abeta25-35 in mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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