Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats.

Adeghate E, Ponery AS

Neuro endocrinology letters1 Dec 2004

PMID15665799PepBankPUB-15665799

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In pancreatic tissue from normal rats, ipamorelin increased insulin secretion.
In plain wordsIn lab tests on rat pancreatic tissue, ipamorelin increased insulin release.
Peptide
Ipamorelin
Outcome
IncreaseInsulin secretion, normal rats
Study
ratn: not reported in source
pancreatic tissue fragments of normal rats
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
10(-12) - 10(-6) MAs given in this study (rat).
Source sentences
Summary
Ipamorelin evoked significant (p<0.04) increases in insulin secretion from the pancreas of normal and diabetic rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
Report a problemFND-1566579901
02LabEx vivo tissueEfficacy outcome
In pancreatic tissue from streptozotocin-diabetic rats, ipamorelin increased insulin secretion.
In plain wordsIn lab tests on pancreatic tissue from diabetic rats, ipamorelin increased insulin release.
Peptide
Ipamorelin
Outcome
IncreaseInsulin secretion, diabetic rats
Study
ratn: not reported in source
pancreatic tissue fragments of streptozotocin-diabetic rats
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
10(-12) - 10(-6) MAs given in this study (rat).
Source sentences
Summary
Ipamorelin evoked significant (p<0.04) increases in insulin secretion from the pancreas of normal and diabetic rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
Report a problemFND-1566579902

Studies that did not test the peptide alone6

In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Ipamorelin.

03LabNot a test of Ipamorelin aloneEx vivo tissueMechanism
In rat pancreatic tissue, diltiazem significantly inhibited ipamorelin-evoked insulin secretion.
In plain wordsIn lab tests on rat pancreatic tissue, diltiazem reduced the insulin release triggered by ipamorelin.
Peptide
Ipamorelin
Outcome
DecreaseDiltiazem effect on ipamorelin-evoked insulin secretion
Study
ratn: not reported in source
pancreatic tissue fragments of normal and diabetic rats
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
Either diltiazem or yohimbine or propranolol or a combination of atropine, propranolol and yohimbine inhibited IPA-evoked insulin secretion significantly (p<0.03) from the pancreas of normal and diabetic rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-1566579903
04LabNot a test of Ipamorelin aloneEx vivo tissueMechanism
In rat pancreatic tissue, yohimbine significantly inhibited ipamorelin-evoked insulin secretion.
In plain wordsIn lab tests on rat pancreatic tissue, yohimbine reduced the insulin release triggered by ipamorelin.
Peptide
Ipamorelin
Outcome
DecreaseYohimbine effect on ipamorelin-evoked insulin secretion
Study
ratn: not reported in source
pancreatic tissue fragments of normal and diabetic rats
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
Either diltiazem or yohimbine or propranolol or a combination of atropine, propranolol and yohimbine inhibited IPA-evoked insulin secretion significantly (p<0.03) from the pancreas of normal and diabetic rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-1566579904
05LabNot a test of Ipamorelin aloneEx vivo tissueMechanism
In rat pancreatic tissue, propranolol significantly inhibited ipamorelin-evoked insulin secretion.
In plain wordsIn lab tests on rat pancreatic tissue, propranolol reduced the insulin release triggered by ipamorelin.
Peptide
Ipamorelin
Outcome
DecreasePropranolol effect on ipamorelin-evoked insulin secretion
Study
ratn: not reported in source
pancreatic tissue fragments of normal and diabetic rats
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
Either diltiazem or yohimbine or propranolol or a combination of atropine, propranolol and yohimbine inhibited IPA-evoked insulin secretion significantly (p<0.03) from the pancreas of normal and diabetic rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-1566579905
06LabNot a test of Ipamorelin aloneEx vivo tissueMechanism
In rat pancreatic tissue, the combination of atropine, propranolol and yohimbine significantly inhibited ipamorelin-evoked insulin secretion.
In plain wordsIn lab tests on rat pancreatic tissue, a combination of three blockers reduced the insulin release triggered by ipamorelin.
Peptide
Ipamorelin
Outcome
DecreaseAtropine, propranolol and yohimbine combination effect on ipamorelin-evoked insulin secretion
Study
ratn: not reported in source
pancreatic tissue fragments of normal and diabetic rats
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
Either diltiazem or yohimbine or propranolol or a combination of atropine, propranolol and yohimbine inhibited IPA-evoked insulin secretion significantly (p<0.03) from the pancreas of normal and diabetic rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-1566579906
07LabNot a test of Ipamorelin aloneEx vivo tissueMechanism
In pancreatic tissue from diabetic rats, atropine significantly reduced ipamorelin-induced insulin secretion.
In plain wordsIn lab tests on pancreatic tissue from diabetic rats, atropine reduced the insulin release triggered by ipamorelin.
Peptide
Ipamorelin
Outcome
DecreaseAtropine effect on ipamorelin-induced insulin secretion, diabetic rats
Study
ratn: not reported in source
pancreatic tissue fragments of streptozotocin-diabetic rats
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
Atropine caused a significant (p<0.007) reduction in the IPA-induced insulin secretion in diabetic but not in normal rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-1566579907
08LabNot a test of Ipamorelin aloneEx vivo tissueMechanism
In pancreatic tissue from normal rats, atropine did not significantly reduce ipamorelin-induced insulin secretion.
In plain wordsIn lab tests on pancreatic tissue from normal rats, atropine did not reduce the insulin release triggered by ipamorelin.
Peptide
Ipamorelin
Outcome
No significant changeAtropine effect on ipamorelin-induced insulin secretion, normal rats
Study
ratn: not reported in source
pancreatic tissue fragments of normal rats
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
Atropine caused a significant (p<0.007) reduction in the IPA-induced insulin secretion in diabetic but not in normal rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were removed and incubated with different concentrations (10(-12) - 10(-6) M) of IPA.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-1566579908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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