Skip to content

Study · In vitro (cells) · rat · 2005

3 results

Ghrelin regulates proliferation and differentiation of osteoblastic cells.

Maccarinelli G, Sibilia V, Torsello A, Raimondo F, Pitto M, Giustina A, Netti C, Cocchi D

The Journal of endocrinology1 Jan 2005Cited by 133 (Europe PMC)

PMID15642801 (opens in a new tab)DOI10.1677/joe.1.05837 (opens in a new tab)PepBankPUB-15642801
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In primary rat calvaria osteoblasts, hexarelin significantly stimulated osteoblast proliferation at low concentrations.

    In plain wordsIn rat bone cells in the lab, hexarelin increased cell growth at low concentrations.

    Peptide
    Hexarelin
    Outcome
    IncreaseOsteoblast proliferation
    Study

    ratn: not reported in source

    primary cultures of rat calvaria osteoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10(-11)-10(-8) M · added to cell cultureAs given in this study (rat).

    Source sentences

    Summary
    Both ghrelin and HEXA (10(-11)-10(-8) M) significantly stimulated osteoblast proliferation at low concentrations (10(-10) M).
    1 context sentence
    Summary · context
    In this study we evaluated the effect of ghrelin, the endogenous ligand of GHS receptors, on the proliferation rate and on osteoblast activity in primary cultures of rat calvaria osteoblasts.
  2. 02LabIn vitro (cells)Efficacy outcome

    In primary rat calvaria osteoblasts, hexarelin significantly increased alkaline phosphatase production.

    In plain wordsIn rat bone cells in the lab, hexarelin increased production of alkaline phosphatase, a bone cell marker.

    Peptide
    Hexarelin
    Outcome
    IncreaseAlkaline phosphatase production
    Study

    ratn: not reported in source

    primary cultures of rat calvaria osteoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ghrelin and HEXA significantly increased alkaline phosphatase (ALP) and osteocalcin (OC) production.
    1 context sentence
    Summary · context
    In this study we evaluated the effect of ghrelin, the endogenous ligand of GHS receptors, on the proliferation rate and on osteoblast activity in primary cultures of rat calvaria osteoblasts.
  3. 03LabIn vitro (cells)Efficacy outcome

    In primary rat calvaria osteoblasts, hexarelin significantly increased osteocalcin production.

    In plain wordsIn rat bone cells in the lab, hexarelin increased production of osteocalcin, a bone cell marker.

    Peptide
    Hexarelin
    Outcome
    IncreaseOsteocalcin production
    Study

    ratn: not reported in source

    primary cultures of rat calvaria osteoblasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ghrelin and HEXA significantly increased alkaline phosphatase (ALP) and osteocalcin (OC) production.
    1 context sentence
    Summary · context
    In this study we evaluated the effect of ghrelin, the endogenous ligand of GHS receptors, on the proliferation rate and on osteoblast activity in primary cultures of rat calvaria osteoblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.