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Study · Animal study (in vivo) · rat · 2004

6 results

Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat.

Sibilia V, Torsello A, Pagani F, Rapetti D, Lattuada N, Locatelli V, Bulgarelli I, Guidobono F, Netti C

Peptides1 Dec 2004Cited by 11 (Europe PMC)

PMID15572206 (opens in a new tab)DOI10.1016/j.peptides.2004.08.001 (opens in a new tab)PepBankPUB-15572206
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular hexarelin (1 nmol/rat) reduced ethanol-induced gastric ulcers by 47%.

    In plain wordsIn rats, hexarelin given into the brain cut stomach ulcers caused by ethanol by 47%.

    Peptide
    Hexarelin
    Outcome
    DecreaseEthanol-induced gastric ulcers, icv hexarelin
    Study

    ratn: not reported in source

    Conscious rats with gastric ulcers
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    1 nmol/rat · intracerebroventricularAs given in this study (rat).

    Measurements

    Ulcer reduction
    47%
    icv 1 nmol/rat

    Source sentences

    Summary
    Hexa at 1 nmol/rat, icv or 10 nmol/kg, sc reduced ethanol-induced ulcers by 47% and 32% respectively.
    1 context sentence
    Summary · context
    The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, subcutaneous hexarelin (10 nmol/kg) reduced ethanol-induced gastric ulcers by 32%.

    In plain wordsIn rats, hexarelin given under the skin cut stomach ulcers caused by ethanol by 32%.

    Peptide
    Hexarelin
    Outcome
    DecreaseEthanol-induced gastric ulcers, sc hexarelin
    Study

    ratn: not reported in source

    Conscious rats with gastric ulcers
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 nmol/kg · subcutaneousAs given in this study (rat).

    Measurements

    Ulcer reduction
    32%
    sc 10 nmol/kg

    Source sentences

    Summary
    Hexa at 1 nmol/rat, icv or 10 nmol/kg, sc reduced ethanol-induced ulcers by 47% and 32% respectively.
    1 context sentence
    Summary · context
    The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In rats, subcutaneous hexarelin, but not ghrelin, significantly worsened indomethacin-induced gastric ulcers by 40%.

    In plain wordsIn rats, hexarelin under the skin made stomach ulcers from indomethacin worse by 40%, while ghrelin did not.

    Peptide
    Hexarelin
    Outcome
    IncreaseIndomethacin-induced gastric ulcers, sc hexarelin
    Study

    ratn: not reported in source

    Conscious rats with gastric ulcers
    Comparator
    Ghrelin
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Measurements

    Ulcer worsening
    40%
    sc hexarelin

    Source sentences

    Summary
    Hexa, but not ghrelin significantly worsened (+40%) Indomethacin-induced ulcers when injected sc.
    1 context sentence
    Summary · context
    The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, the GHS-R antagonist (D-Lys3)-GRPR-6 removed hexarelin gastroprotection against ethanol-induced ulcers.

    In plain wordsIn rats, blocking the growth hormone secretagogue receptor removed the stomach protection that hexarelin gave against ethanol.

    Peptide
    Hexarelin
    Outcome
    No significant changeHexarelin gastroprotection with GHS-R antagonist
    Study

    ratn: not reported in source

    Conscious rats with gastric ulcers
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexa-gastroprotection against ethanol-induced ulcers was removed by the GHS-R antagonist (D-Lys3)-GRPR-6
    1 context sentence
    Summary · context
    The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, the NO-synthase inhibitor L-NAME removed hexarelin gastroprotection against ethanol-induced ulcers.

    In plain wordsIn rats, blocking nitric oxide production removed the stomach protection that hexarelin gave against ethanol.

    Peptide
    Hexarelin
    Outcome
    No significant changeHexarelin gastroprotection with NOS inhibitor
    Study

    ratn: not reported in source

    Conscious rats with gastric ulcers
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexa-gastroprotection against ethanol-induced ulcers was removed by the GHS-R antagonist (D-Lys3)-GRPR-6 and by the inhibitor of NO-synthase (NOS) Nomega-nitro-L-arginine methyl ester.
    1 context sentence
    Summary · context
    The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, hexarelin gastroprotection against ethanol damage involved a reduction in iNOS-derived NO and an increase in constitutive-derived NO.

    In plain wordsIn rats, hexarelin protected the stomach from ethanol through changes in nitric oxide production.

    Peptide
    Hexarelin
    Outcome
    MixedGastric NOS isoform mRNA after hexarelin
    Study

    ratn: not reported in source

    Conscious rats with gastric ulcers
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semiquantitative RT-PCR assay of gastric NOS mRNA isoforms revealed that the reduction in iNOS-derived NO and the increase of constitutive-derived NO are relevant for the gastroprotection of Hexa against ethanol-induced gastric damage.
    1 context sentence
    Summary · context
    The effects of intracerebroventricular (icv) or subcutaneous (sc) hexarelin (Hexa) administration, against gastric ulcers induced by ethanol (50%, 1 ml/rat/os) or Indomethacin (20 mg/kg/os) were examined in conscious rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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