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Study · Measured the body's own peptide · 2005

4 results

Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality.

Ijiri K, Tsuruga H, Sakakima H, Tomita K, Taniguchi N, Shimoonoda K, Komiya S, Goldring MB, Majima HJ, Matsuyama T

Annals of the rheumatic diseases26 Nov 2004Cited by 14 (Europe PMC)

PMID15567815 (opens in a new tab)PMCIDPMC1755539 (opens in a new tab)DOI10.1136/ard.2004.025445 (opens in a new tab)PepBankPUB-15567815
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In synovial cells, humanin gene expression was strong in diffuse-type pigmented villonodular synovitis and barely detected in nodular-type PVNS, rheumatoid arthritis or osteoarthritis.

    In plain wordsIn joint lining cells, the body's own humanin gene was much more active in diffuse-type PVNS than in the other joint diseases tested.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin gene expression in diffuse-type PVNS
    Study

    n: not reported in source

    Comparator
    Nodular-type PVNS, rheumatoid arthritis, osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Humanin genes were strongly expressed in diffuse-type PVNS, but were barely detected in nodular-type PVNS, rheumatoid arthritis, or osteoarthritis.
    1 context sentence
    Summary · context
    A combination of subtraction cloning and Southern colony hybridisation was used to detect highly expressed genes in PVNS in comparison with rheumatoid synovial cells.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Humanin peptide was identified in synovium from diffuse-type PVNS, mostly in cells of the deep synovial layer.

    In plain wordsNatural humanin peptide was found in joint lining tissue from diffuse-type PVNS, mostly in the deep layer.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin peptide detection in diffuse-type PVNS synovium
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Humanin peptide was identified in synovium from diffuse-type PVNS, and most of the positive cells were distributed in the deep layer of the synovial tissue.
    1 context sentence
    Summary · context
    A combination of subtraction cloning and Southern colony hybridisation was used to detect highly expressed genes in PVNS in comparison with rheumatoid synovial cells.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyMechanism

    Double staining showed that humanin was expressed mainly in mitochondria of diffuse-type PVNS synovial cells.

    In plain wordsNatural humanin was found mainly inside mitochondria, the cell's energy units, in PVNS joint tissue.

    Peptide
    Humanin
    Outcome
    Not applicableSubcellular location of humanin (mitochondria)
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    Double staining with anti-humanin and anti-heat shock protein 60 showed that humanin was expressed mainly in mitochondria.
    1 context sentence
    Summary · context
    A combination of subtraction cloning and Southern colony hybridisation was used to detect highly expressed genes in PVNS in comparison with rheumatoid synovial cells.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyMechanism

    Electron microscopy located humanin predominantly around dense iron deposits within the siderosome in diffuse-type PVNS.

    In plain wordsNatural humanin was found mostly around iron deposits inside cell compartments in PVNS joint tissue.

    Peptide
    Humanin
    Outcome
    Not applicableSubcellular location of humanin (siderosome)
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    Electron microscopy disclosed immunolocalisation of this peptide, predominantly around dense iron deposits within the siderosome.
    1 context sentence
    Summary · context
    A combination of subtraction cloning and Southern colony hybridisation was used to detect highly expressed genes in PVNS in comparison with rheumatoid synovial cells.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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