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Study · Animal study (in vivo) · mouse · 2004

6 results

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.

Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D

Nature1 Nov 2004Cited by 507 (Europe PMC)

PMID15565145 (opens in a new tab)DOI10.1038/nature03000 (opens in a new tab)PepBankPUB-15565145
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with coronary artery ligation, thymosin beta4 treatment upregulated ILK and Akt activity in the heart.

    In plain wordsIn mice with a blocked heart artery, thymosin beta4 treatment raised ILK and Akt activity in the heart.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseILK and Akt activity in the heart after coronary ligation
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After coronary artery ligation in mice, thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival and improved cardiac function.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with coronary artery ligation, thymosin beta4 treatment enhanced early myocyte survival.

    In plain wordsIn mice with a blocked heart artery, thymosin beta4 treatment improved early heart muscle cell survival.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEarly myocyte survival after coronary ligation
    Study

    mousen: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After coronary artery ligation in mice, thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival and improved cardiac function.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with coronary artery ligation, thymosin beta4 treatment improved cardiac function.

    In plain wordsIn mice with a blocked heart artery, thymosin beta4 treatment improved heart function.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiac function after coronary ligation
    Study

    mousen: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After coronary artery ligation in mice, thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival and improved cardiac function.
  4. 04LabIn vitro (cells)Activity measurement

    Thymosin beta4 promoted migration of myocardial and endothelial cells in the embryonic heart and in postnatal cardiomyocytes.

    In plain wordsIn embryonic heart tissue and heart muscle cells, thymosin beta4 increased cell migration.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMyocardial and endothelial cell migration
    Study

    n: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we show that the G-actin sequestering peptide thymosin beta4 promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes.
  5. 05LabIn vitro (cells)Activity measurement

    Thymosin beta4 enhanced the survival of embryonic and postnatal cardiomyocytes in culture.

    In plain wordsIn cultured heart muscle cells, thymosin beta4 improved cell survival.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiomyocyte survival in culture
    Study

    n: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Survival of embryonic and postnatal cardiomyocytes in culture was also enhanced by thymosin beta4.
  6. 06LabIn vitro (cells)Mechanism

    Thymosin beta4 formed a functional complex with PINCH and integrin-linked kinase, which activated the survival kinase Akt.

    In plain wordsIn cells, thymosin beta4 formed a complex with PINCH and ILK that switched on the survival enzyme Akt.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseComplex with PINCH and ILK and Akt activation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that thymosin beta4 formed a functional complex with PINCH and integrin-linked kinase (ILK), resulting in activation of the survival kinase Akt (also known as protein kinase B).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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