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Study · Not a test of the peptide alone · 2005

1 result

Sustained inhibitory effect of Agouti Related Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells.

Doghman M, Delagrange P, Berthelon MC, Durand P, Naville D, Bégeot M

Regulatory peptides1 Jan 2005Cited by 9 (Europe PMC)

PMID15544862 (opens in a new tab)DOI10.1016/j.regpep.2004.07.020 (opens in a new tab)PepBankPUB-15544862
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 01LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Mechanism

    In cultured bovine adrenal cells, Agrp inhibited NDP-alphaMSH-induced cortisol production in a dose-dependent manner.

    In plain wordsIn cells, Agrp reduced the cortisol release caused by NDP-alphaMSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseNDP-alphaMSH-induced cortisol production with Agrp
    Study

    bovinen: not reported in source

    Cultured adrenal cells
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    We showed that Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP-alphaMSH-induced cortisol production through its antagonistic properties towards MSH at the level of MC4-R.
    1 context sentence
    Summary · context
    In this report, we studied the effects of a long-term treatment (24 h) of cultured bovine adrenal cells by Agrp on the (Nle4, d-Phe7)-alphaMSH (NDP-alphaMSH)- or ACTH-induced cortisol release.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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