In primary porcine hepatocytes, hexarelin had no effect on glucose output, unlike acylated ghrelin.
In plain wordsIn pig liver cells in the lab, hexarelin did not change glucose output, while acylated ghrelin raised it.
- Peptide
- Hexarelin
- Outcome
- No significant changeHepatocyte glucose output
- Study
pign: not reported in source
primary porcine hepatocytes in suspension culture- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- Dose not stated · incubation in cell cultureAs given in this study (pig).
Source sentences
AG induced glucose output dose dependently after 20 min of incubation (P < 0.001), whereas HEX, a GH secretagogue receptor type 1a (GHS-R1a) agonist, had no effect.
1 context sentence(design, population, supporting numbers)
To verify whether the glucose response to ghrelin reflects a modulation of an insulin-independent hepatic phenomenon, we studied glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX).