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Study · Animal study (in vivo) · rat · 2004

12 results

Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements.

Tohyama Y, Sikirić P, Diksic M

Life sciences1 Dec 2004Cited by 32 (Europe PMC)

PMID15531385 (opens in a new tab)DOI10.1016/j.lfs.2004.08.010 (opens in a new tab)PepBankPUB-15531385
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, a single dose of BPC157 significantly reduced the regional rate of serotonin synthesis in the dorsal thalamus.

    In plain wordsIn rats, one dose of BPC‑157 lowered serotonin production in a brain region called the dorsal thalamus.

    Peptide
    BPC-157
    Outcome
    Decrease5-HT synthesis in dorsal thalamus, single dose
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the first series of experiments, a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection significantly reduced the regional rate of 5-HT synthesis in the dorsal thalamus, hippocampus, lateral geniculate body and hypothalamus.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, a single dose of BPC157 significantly reduced the regional rate of serotonin synthesis in the hippocampus.

    In plain wordsIn rats, one dose of BPC‑157 lowered serotonin production in the hippocampus.

    Peptide
    BPC-157
    Outcome
    Decrease5-HT synthesis in hippocampus, single dose
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the first series of experiments, a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection significantly reduced the regional rate of 5-HT synthesis in the dorsal thalamus, hippocampus, lateral geniculate body and hypothalamus.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, a single dose of BPC157 significantly reduced the regional rate of serotonin synthesis in the lateral geniculate body.

    In plain wordsIn rats, one dose of BPC‑157 lowered serotonin production in the lateral geniculate body of the brain.

    Peptide
    BPC-157
    Outcome
    Decrease5-HT synthesis in lateral geniculate body, single dose
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the first series of experiments, a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection significantly reduced the regional rate of 5-HT synthesis in the dorsal thalamus, hippocampus, lateral geniculate body and hypothalamus.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, a single dose of BPC157 significantly reduced the regional rate of serotonin synthesis in the hypothalamus.

    In plain wordsIn rats, one dose of BPC‑157 lowered serotonin production in the hypothalamus.

    Peptide
    BPC-157
    Outcome
    Decrease5-HT synthesis in hypothalamus, single dose
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the first series of experiments, a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection significantly reduced the regional rate of 5-HT synthesis in the dorsal thalamus, hippocampus, lateral geniculate body and hypothalamus.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats treated with BPC157, serotonin synthesis in the substantia nigra reticulate was significantly higher than in control rats.

    In plain wordsIn rats, BPC‑157 raised serotonin production in the substantia nigra reticulata compared with control rats.

    Peptide
    BPC-157
    Outcome
    Increase5-HT synthesis in substantia nigra reticulata, single dose
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Comparator
    Control rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    5-HT synthesis rates in the substantia nigra reticulate and medial anterior olfactory nucleus in BPC157 treated rats were significantly higher than in the control rats.
    2 context sentences
    Summary · context
    a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats treated with BPC157, serotonin synthesis in the medial anterior olfactory nucleus was significantly higher than in control rats.

    In plain wordsIn rats, BPC‑157 raised serotonin production in the medial anterior olfactory nucleus compared with control rats.

    Peptide
    BPC-157
    Outcome
    Increase5-HT synthesis in medial anterior olfactory nucleus, single dose
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Comparator
    Control rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    5-HT synthesis rates in the substantia nigra reticulate and medial anterior olfactory nucleus in BPC157 treated rats were significantly higher than in the control rats.
    2 context sentences
    Summary · context
    a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, a single dose of BPC157 caused no significant change in the serotonin synthesis rate in the raphe nuclei.

    In plain wordsIn rats, one dose of BPC‑157 did not change serotonin production in the raphe nuclei of the brain.

    Peptide
    BPC-157
    Outcome
    No significant change5-HT synthesis in raphe nuclei, single dose
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    No significant change in the synthesis rate was observed in the raphe nuclei.
    2 context sentences
    Summary · context
    a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, 7-day treatment with BPC157 significantly reduced the serotonin synthesis rate in the dorsal raphe nucleus.

    In plain wordsIn rats, seven days of BPC‑157 lowered serotonin production in the dorsal raphe nucleus.

    Peptide
    BPC-157
    Outcome
    Decrease5-HT synthesis in dorsal raphe nucleus, 7-day treatment
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the second series of experiments, following a 7-day treatment with BPC157 (10 microg/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats, 7-day treatment with BPC157 significantly increased the serotonin synthesis rate in the substantia nigra.

    In plain wordsIn rats, seven days of BPC‑157 raised serotonin production in the substantia nigra.

    Peptide
    BPC-157
    Outcome
    Increase5-HT synthesis in substantia nigra, 7-day treatment
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the second series of experiments, following a 7-day treatment with BPC157 (10 microg/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats, 7-day treatment with BPC157 significantly increased the serotonin synthesis rate in the lateral caudate.

    In plain wordsIn rats, seven days of BPC‑157 raised serotonin production in the lateral caudate.

    Peptide
    BPC-157
    Outcome
    Increase5-HT synthesis in lateral caudate, 7-day treatment
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the second series of experiments, following a 7-day treatment with BPC157 (10 microg/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats, 7-day treatment with BPC157 significantly increased the serotonin synthesis rate in the accumbens nucleus.

    In plain wordsIn rats, seven days of BPC‑157 raised serotonin production in the accumbens nucleus.

    Peptide
    BPC-157
    Outcome
    Increase5-HT synthesis in accumbens nucleus, 7-day treatment
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the second series of experiments, following a 7-day treatment with BPC157 (10 microg/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In rats, 7-day treatment with BPC157 significantly increased the serotonin synthesis rate in the superior olive.

    In plain wordsIn rats, seven days of BPC‑157 raised serotonin production in the superior olive.

    Peptide
    BPC-157
    Outcome
    Increase5-HT synthesis in superior olive, 7-day treatment
    Study

    ratn: not reported in source

    Alpha-methyl-L-tryptophan autoradiography of brain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 microg/kg · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In the second series of experiments, following a 7-day treatment with BPC157 (10 microg/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive.
    1 context sentence
    Summary · context
    The alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method was used to measure regional 5-HT synthesis rates.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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