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Study · Animal study (in vivo) · rat · 2004

12 results

Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

Thompson EL, Patterson M, Murphy KG, Smith KL, Dhillo WS, Todd JF, Ghatei MA, Bloom SR

Journal of neuroendocrinology1 Oct 2004Cited by 367 (Europe PMC)

PMID15500545 (opens in a new tab)DOI10.1111/j.1365-2826.2004.01240.x (opens in a new tab)PepBankPUB-15500545
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, intracerebroventricular kisspeptin‑10 raised plasma LH in a dose-dependent way at 60 min.

    In plain wordsIn male rats, kisspeptin‑10 given into the brain raised LH, and higher doses gave a larger rise.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after i.c.v. kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The i.c.v. administration of kisspeptin-10 dose-dependently increased plasma luteinizing hormone (LH) and increased plasma follicle stimulating hormone (FSH) and total testosterone at 60 min postinjection.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, intracerebroventricular kisspeptin‑10 raised plasma FSH at 60 min.

    In plain wordsIn male rats, kisspeptin‑10 given into the brain raised FSH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma FSH after i.c.v. kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The i.c.v. administration of kisspeptin-10 dose-dependently increased plasma luteinizing hormone (LH) and increased plasma follicle stimulating hormone (FSH) and total testosterone at 60 min postinjection.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, intracerebroventricular kisspeptin‑10 raised plasma total testosterone at 60 min.

    In plain wordsIn male rats, kisspeptin‑10 given into the brain raised testosterone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma total testosterone after i.c.v. kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The i.c.v. administration of kisspeptin-10 dose-dependently increased plasma luteinizing hormone (LH) and increased plasma follicle stimulating hormone (FSH) and total testosterone at 60 min postinjection.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, 3 nmol intracerebroventricular kisspeptin‑10 raised plasma LH at 10, 20 and 60 min.

    In plain wordsIn male rats, kisspeptin‑10 given into the brain raised LH at 10, 20 and 60 minutes.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH time course after 3 nmol i.c.v. kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    i.c.v. administered kisspeptin-10 (3 nmol) significantly increased plasma LH at 10, 20 and 60 min, FSH at 60 min and total testosterone at 20 and 60 min postinjection.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, 3 nmol intracerebroventricular kisspeptin‑10 raised plasma FSH at 60 min.

    In plain wordsIn male rats, kisspeptin‑10 given into the brain raised FSH at 60 minutes.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma FSH time course after 3 nmol i.c.v. kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    i.c.v. administered kisspeptin-10 (3 nmol) significantly increased plasma LH at 10, 20 and 60 min, FSH at 60 min and total testosterone at 20 and 60 min postinjection.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, 3 nmol intracerebroventricular kisspeptin‑10 raised plasma total testosterone at 20 and 60 min.

    In plain wordsIn male rats, kisspeptin‑10 given into the brain raised testosterone at 20 and 60 minutes.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma total testosterone time course after 3 nmol i.c.v. kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    i.c.v. administered kisspeptin-10 (3 nmol) significantly increased plasma LH at 10, 20 and 60 min, FSH at 60 min and total testosterone at 20 and 60 min postinjection
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, peripheral kisspeptin‑10 raised plasma LH.

    In plain wordsIn male rats, kisspeptin‑10 given outside the brain raised LH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after peripheral kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Peripheral administration of kisspeptin-10 increased plasma LH, FSH and total testosterone.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, peripheral kisspeptin‑10 raised plasma FSH.

    In plain wordsIn male rats, kisspeptin‑10 given outside the brain raised FSH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma FSH after peripheral kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Peripheral administration of kisspeptin-10 increased plasma LH, FSH and total testosterone.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, peripheral kisspeptin‑10 raised plasma total testosterone.

    In plain wordsIn male rats, kisspeptin‑10 given outside the brain raised testosterone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma total testosterone after peripheral kisspeptin-10
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    Peripheral administration of kisspeptin-10 increased plasma LH, FSH and total testosterone.
    1 context sentence
    Summary · context
    We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone levels in adult male rats.
  10. 10LabEx vivo tissueActivity measurement

    In in vitro hypothalamic explants, kisspeptin‑10 stimulated release of LHRH.

    In plain wordsIn lab tests on brain tissue, kisspeptin‑10 raised the release of LHRH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLHRH release from hypothalamic explants
    Study

    n: not reported in source

    hypothalamic explants
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · in vitroAs given in this study.

    Source sentences

    Summary
    Kisspeptin-10 stimulated the release of luteinizing hormone-releasing hormone (LHRH) from in vitro hypothalamic explants.
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 in vitro on the release of hypothalamic peptides from hypothalamic explants and gonadotrophins from anterior pituitary fragments was also determined.
  11. 11LabEx vivo tissueActivity measurement

    In in vitro anterior pituitary fragments, kisspeptin‑10 at 100-1000 nM did not change LH release.

    In plain wordsIn lab tests on pituitary tissue, kisspeptin‑10 did not change LH release.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH release from pituitary fragments
    Study

    n: not reported in source

    anterior pituitary fragments
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100-1000 nM · in vitroAs given in this study.

    Source sentences

    Summary
    However, doses of 100-1000 nM kisspeptin-10 did not influence LH or FSH release from pituitary fragments in vitro.
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 in vitro on the release of hypothalamic peptides from hypothalamic explants and gonadotrophins from anterior pituitary fragments was also determined.
  12. 12LabEx vivo tissueActivity measurement

    In in vitro anterior pituitary fragments, kisspeptin‑10 at 100-1000 nM did not change FSH release.

    In plain wordsIn lab tests on pituitary tissue, kisspeptin‑10 did not change FSH release.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeFSH release from pituitary fragments
    Study

    n: not reported in source

    anterior pituitary fragments
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100-1000 nM · in vitroAs given in this study.

    Source sentences

    Summary
    However, doses of 100-1000 nM kisspeptin-10 did not influence LH or FSH release from pituitary fragments in vitro.
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 in vitro on the release of hypothalamic peptides from hypothalamic explants and gonadotrophins from anterior pituitary fragments was also determined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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