[Simplified gonadorelin stimulation test in diagnosis of precocious puberty].

Jiang YJ, Liang L, Zhouliang ZC, Fu JF, Li Y, Hong F, Dong GP

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences1 Sept 2004Cited by 2 (Europe PMC)

PMID15476332DOI10.3785/j.issn.1008-9292.2004.05.017PepBankPUB-15476332

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. 4 results from people.

01HumanObservational studyOther
In girls with advanced breast development, an LH/FSH ratio above 0.9 after gonadorelin had a sensitivity of 80.1%, 68.9% and 38.4% and a specificity of 90.8%, 96.6% and 69.7% at 15, 30 and 60 min.
In plain wordsIn girls with early breast development, an LH/FSH ratio above 0.9 after gonadorelin found 80.1% of cases at 15 minutes and 38.4% at 60 minutes.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableDiagnostic value of LH/FSH ratio above 0.9 after gonadorelin
Study
n = 292
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Sensitivity
80.1%
15 min
Sensitivity
68.9%
30 min
Sensitivity
38.4%
60 min
Specificity
90.8%
15 min
Specificity
96.6%
30 min
Specificity
69.7%
60 min
Source sentences
Summary
Taking the LH/FSH ratio >0.9 at 15 min, 30 min, 60 min as cut-off value, the diagnostic sensitivity was 80.1%, 68.9% and 38.4%, and the specificity was 90.8%, 96.6% and 69.7%, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred and ninety-two girls with signs of advanced breast development received the gonadorelin stimulation test.
Summary · context
According to the result of gonadorelin stimulation test, the girls were divided into 3 groups: 151 with central precocious puberty (CPP),119 with premature thelarche (PT) and 22 with peripheral precocious puberty (PPP).
Report a problemFND-1547633205
02HumanObservational studyActivity measurement
In girls with central precocious puberty, LH and FSH levels at 15, 30 and 60 min after gonadorelin were significantly different, with the highest levels at 30 min.
In plain wordsIn girls with central precocious puberty, LH and FSH changed significantly after gonadorelin, with the highest levels at 30 minutes.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreaseLH and FSH response over time, central precocious puberty group
Study
n = 151
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
LH or FSH levels at 15 min, 30 min, 60 min in CPP group were significantly different (P<0.01) with the highest levels at 30 min.
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred and ninety-two girls with signs of advanced breast development received the gonadorelin stimulation test.
Summary · context
According to the result of gonadorelin stimulation test, the girls were divided into 3 groups: 151 with central precocious puberty (CPP),119 with premature thelarche (PT) and 22 with peripheral precocious puberty (PPP).
Report a problemFND-1547633203
03HumanObservational studyActivity measurement
In girls with premature thelarche, LH and FSH levels at 15, 30 and 60 min after gonadorelin were significantly different, with the highest LH at 30 min and the highest FSH at 60 min.
In plain wordsIn girls with premature thelarche, LH and FSH changed significantly after gonadorelin, with LH highest at 30 minutes and FSH at 60 minutes.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreaseLH and FSH response over time, premature thelarche group
Study
n = 119
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Those were significantly different in PT group (P<0.01). The highest levels of LH were at 30 min and the highest levels of FSH were at 60 min.
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred and ninety-two girls with signs of advanced breast development received the gonadorelin stimulation test.
Summary · context
According to the result of gonadorelin stimulation test, the girls were divided into 3 groups: 151 with central precocious puberty (CPP),119 with premature thelarche (PT) and 22 with peripheral precocious puberty (PPP).
Report a problemFND-1547633202
04HumanObservational studyActivity measurement
In girls with peripheral precocious puberty, LH and FSH levels at 15, 30 and 60 min after gonadorelin were not significantly different.
In plain wordsIn girls with peripheral precocious puberty, LH and FSH did not change significantly at 15, 30 and 60 minutes after gonadorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeLH and FSH response over time, peripheral precocious puberty group
Study
n = 22
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
LH or FSH levels at 15 min, 30 min, 60 min in PPP group were not significantly different (P>0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred and ninety-two girls with signs of advanced breast development received the gonadorelin stimulation test.
Summary · context
According to the result of gonadorelin stimulation test, the girls were divided into 3 groups: 151 with central precocious puberty (CPP),119 with premature thelarche (PT) and 22 with peripheral precocious puberty (PPP).
Report a problemFND-1547633201

Studies that did not test the peptide alone1

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

05HumanNot a test of Gonadorelin (GnRH, LHRH) aloneObservational studyOther
In girls with advanced breast development, a basal LH/FSH ratio above 0.2 had a diagnostic sensitivity of 48.3% and specificity of 69.7%.
In plain wordsIn girls with early breast development, a basal LH/FSH ratio above 0.2 found 48.3% of cases and correctly cleared 69.7% of non-cases.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableDiagnostic value of basal LH/FSH ratio above 0.2
Study
n = 292
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Sensitivity
48.3%
basal LH/FSH ratio >0.2
Specificity
69.7%
basal LH/FSH ratio >0.2
Source sentences
Summary
The ratio of basal LH and FSH >0.2 had a diagnostic sensitivity of 48.3 % and specificity of 69.7%.
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred and ninety-two girls with signs of advanced breast development received the gonadorelin stimulation test.
Summary · context
According to the result of gonadorelin stimulation test, the girls were divided into 3 groups: 151 with central precocious puberty (CPP),119 with premature thelarche (PT) and 22 with peripheral precocious puberty (PPP).
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-1547633204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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MeSH terms

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