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Study · Animal study (in vivo) · mouse · 2004

2 results

The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice.

Blagaic AB, Blagaic V, Romic Z, Sikiric P

European journal of pharmacology1 Sept 2004Cited by 25 (Europe PMC)

PMID15381050 (opens in a new tab)DOI10.1016/j.ejphar.2004.07.112 (opens in a new tab)PepBankPUB-15381050
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male mice given acute ethanol, BPC‑157 given before or after ethanol strongly opposed acute intoxication.

    In plain wordsIn mice given a high dose of alcohol, BPC‑157 strongly reduced the signs of acute alcohol poisoning.

    Peptide
    BPC-157
    Outcome
    DecreaseAcute alcohol intoxication (anesthesia, hypothermia, blood ethanol, fatality)
    Study

    mousen: not reported in source

    Acute alcohol intoxication and ethanol withdrawal
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    10 pg, 10 ng or 10 microg · intraperitoneal or intragastricAs given in this study (mouse).

    Source sentences

    Summary
    strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25% fatality, 90-min assessment period)
    1 context sentence
    Summary · context
    in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 microg, intraperitoneally or intragastrically)
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male mice after 13 days of 20% alcohol drinking, BPC‑157 given after abrupt cessation of ethanol attenuated withdrawal.

    In plain wordsIn mice withdrawn from alcohol, BPC‑157 given after stopping alcohol reduced withdrawal signs.

    Peptide
    BPC-157
    Outcome
    DecreaseEthanol withdrawal after 13 days of alcohol drinking
    Study

    mousen: not reported in source

    Acute alcohol intoxication and ethanol withdrawal
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    10 pg, 10 ng or 10 microg · intraperitoneal or intragastricAs given in this study (mouse).

    Source sentences

    Summary
    when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours)
    1 context sentence
    Summary · context
    in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 microg, intraperitoneally or intragastrically)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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