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Study · Animal study (in vivo) · rat · 2004

5 results

Hexarelin modulates the expression of growth hormone secretagogue receptor type 1a mRNA at hypothalamic and pituitary sites.

Bresciani E, Nass R, Torsello A, Gaylinn B, Avallone R, Locatelli V, Thorner MO, Müller EE

Neuroendocrinology10 Sept 2004Cited by 8 (Europe PMC)

PMID15361691 (opens in a new tab)DOI10.1159/000080793 (opens in a new tab)PepBankPUB-15361691
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In normal infant rats, hexarelin treatment increased pituitary GHS-R1a mRNA levels.

    In plain wordsIn infant rats, hexarelin raised the amount of its own receptor message in the pituitary.

    Peptide
    Hexarelin
    Outcome
    IncreasePituitary GHS-R1a mRNA in normal infant rats
    Study

    ratn: not reported in source

    Infant (10 days) and young adult rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment significantly increased pituitary and hypothalamic GHS-R1a mRNA levels in normal infant rats
    1 context sentence
    Summary · context
    In this study, we tested whether (a) the synthetic GHS hexarelin regulates mRNA expression of its own receptor at the pituitary and/or hypothalamus and whether this effect is age dependent, and (b) whether short-term treatment with GHRH or, conversely, passive immunization against GHRH affects pitui…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In normal infant rats, hexarelin treatment increased hypothalamic GHS-R1a mRNA levels.

    In plain wordsIn infant rats, hexarelin raised the amount of its own receptor message in the hypothalamus.

    Peptide
    Hexarelin
    Outcome
    IncreaseHypothalamic GHS-R1a mRNA in normal infant rats
    Study

    ratn: not reported in source

    Infant (10 days) and young adult rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment significantly increased pituitary and hypothalamic GHS-R1a mRNA levels in normal infant rats
    1 context sentence
    Summary · context
    In this study, we tested whether (a) the synthetic GHS hexarelin regulates mRNA expression of its own receptor at the pituitary and/or hypothalamus and whether this effect is age dependent, and (b) whether short-term treatment with GHRH or, conversely, passive immunization against GHRH affects pitui…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In normal young adult rats, hexarelin treatment did not significantly change pituitary or hypothalamic GHS-R1a mRNA levels.

    In plain wordsIn young adult rats, hexarelin did not change receptor message in the pituitary or hypothalamus.

    Peptide
    Hexarelin
    Outcome
    No significant changePituitary and hypothalamic GHS-R1a mRNA in normal young adult rats
    Study

    ratn: not reported in source

    Infant (10 days) and young adult rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin treatment significantly increased pituitary and hypothalamic GHS-R1a mRNA levels in normal infant rats, but not in normal young adult rats.
    1 context sentence
    Summary · context
    In this study, we tested whether (a) the synthetic GHS hexarelin regulates mRNA expression of its own receptor at the pituitary and/or hypothalamus and whether this effect is age dependent, and (b) whether short-term treatment with GHRH or, conversely, passive immunization against GHRH affects pitui…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In infant rats passively immunized against GHRH, hexarelin increased pituitary GHS-R1a mRNA.

    In plain wordsIn infant rats lacking GHRH, hexarelin raised receptor message in the pituitary.

    Peptide
    Hexarelin
    Outcome
    IncreasePituitary GHS-R1a mRNA in infant rats immunized against GHRH
    Study

    ratn: not reported in source

    Infant (10 days) and young adult rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    hexarelin administration also stimulated pituitary GHS-R1a mRNA in infant
    1 context sentence
    Summary · context
    In this study, we tested whether (a) the synthetic GHS hexarelin regulates mRNA expression of its own receptor at the pituitary and/or hypothalamus and whether this effect is age dependent, and (b) whether short-term treatment with GHRH or, conversely, passive immunization against GHRH affects pitui…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In young adult rats passively immunized against GHRH, hexarelin increased pituitary GHS-R1a mRNA.

    In plain wordsIn young adult rats lacking GHRH, hexarelin raised receptor message in the pituitary.

    Peptide
    Hexarelin
    Outcome
    IncreasePituitary GHS-R1a mRNA in young adult rats immunized against GHRH
    Study

    ratn: not reported in source

    Infant (10 days) and young adult rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, hexarelin administration also stimulated pituitary GHS-R1a mRNA in infant as well as in young adult rats passively immunized against GHRH.
    1 context sentence
    Summary · context
    In this study, we tested whether (a) the synthetic GHS hexarelin regulates mRNA expression of its own receptor at the pituitary and/or hypothalamus and whether this effect is age dependent, and (b) whether short-term treatment with GHRH or, conversely, passive immunization against GHRH affects pitui…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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