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Study · In vitro (cells) · 2004

1 result

Pegvisomant, a growth hormone-specific antagonist, undergoes cellular internalization.

Maamra M, Kopchick JJ, Strasburger CJ, Ross RJ

The Journal of clinical endocrinology and metabolism1 Sept 2004Cited by 13 (Europe PMC)

PMID15356058 (opens in a new tab)DOI10.1210/jc.2003-031781 (opens in a new tab)PepBankPUB-15356058
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In GHR-expressing cells, pegvisomant underwent cellular internalization despite its size and prolonged plasma half-life.

    In plain wordsIn cells with GH receptors, pegvisomant entered the cells.

    Peptide
    Pegvisomant
    Outcome
    Not applicableCellular internalization
    Study

    n: not reported in source

    GHR-expressing cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have studied pegvisomant internalization and demonstrate that despite its size and prolonged plasma half-life, it is internalized by cells expressing the GHR.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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