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Study · Measured the body's own peptide · 2004

2 results

Regulated transcripts in the hippocampus following transections of the entorhinal afferents.

Ying GX, Liu X, Wang WY, Wang Y, Dong JH, Jin HF, Huang C, Zhou CF

Biochemical and biophysical research communications1 Sept 2004Cited by 5 (Europe PMC)

PMID15313193 (opens in a new tab)DOI10.1016/j.bbrc.2004.07.099 (opens in a new tab)PepBankPUB-15313193
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, thymosin-beta4 transcript expression increased in the hippocampus 10 days after removal of the entorhinal afferents, confirmed by Northern blot.

    In plain wordsIn rats, the body's own thymosin-beta4 transcripts rose in the hippocampus after nerve input from the entorhinal area was cut.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin-beta4 transcript expression in hippocampus after entorhinal deafferentation
    Study

    ratn: not reported in source

    hippocampus after transection of entorhinal afferents
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Based on the data from a cDNA microarray experiment which was carried out to screen the differential expressed genes in the rat hippocampus 10 days after removal of the entorhinal afferents, we confirmed the increase of expression of eight transcripts encoding protein osteonectin, thymosin-beta4, ge…

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, up-regulation of thymosin-beta4 and seven other transcripts localized specifically to the denervated target areas of the hippocampus.

    In plain wordsIn rats, the rise in the body's own thymosin-beta4 transcripts occurred in the hippocampal areas that lost nerve input.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLocalization of thymosin-beta4 transcript up-regulation
    Study

    ratn: not reported in source

    hippocampus after transection of entorhinal afferents
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In situ hybridization revealed that the up-regulation of all these 8 transcripts localized specifically in the denervated target areas, the hippocampal stratum lacunosum-moleculare, and the dentate outer molecular layer.
    1 context sentence
    Summary · context
    Based on the data from a cDNA microarray experiment which was carried out to screen the differential expressed genes in the rat hippocampus 10 days after removal of the entorhinal afferents, we confirmed the increase of expression of eight transcripts encoding protein osteonectin, thymosin-beta4, ge…

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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