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Study · Non-randomized trial · n = 6 · 2004

3 results

Age-related differences in growth hormone (GH) regulation during strenuous exercise.

de Vries WR, Lambers M, van Zanten DP, Osman-Dualeh M, Maitimu I, Koppeschaar HP

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme1 Jul 2004Cited by 2 (Europe PMC)

PMID15305235 (opens in a new tab)DOI10.1055/s-2004-825722 (opens in a new tab)PepBankPUB-15305235
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In younger men, hexarelin alone produced a larger GH response (AUC 919) than exercise (509) or GHRH alone (119).

    In plain wordsIn younger men, hexarelin raised growth hormone more than exercise or GHRH alone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response (AUC) to hexarelin alone in younger men
    Study

    n = 6

    Comparator
    Exercise and GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GH AUC
    919 micro g/l x 120 min
    Hex alone, younger
    GH AUC
    509 micro g/l x 120 min
    exercise, younger
    GH AUC
    119 micro g/l x 120 min
    GHRH alone, younger

    Source sentences

    Summary
    In younger males, the mean AUC to EX (509, range 0 - 1,151) was larger than to GHRH (119, range 0 - 543), but less than that to Hex (919, range 0 - 1,892).
    1 context sentence
    Summary · context
    Twelve male subjects, six in their early-to-mid twenties and six in their late sixties or seventies, received a strong GH stimulus either as incremental EX until volitional exhaustion or by administration of GHRH alone or Hex alone two hours after a presumed maximal GH response to combined administr…
  2. 02HumanNon-randomized trialActivity measurement

    In older men, the GH response to hexarelin alone (AUC 1,077) was preserved, while responses to exercise and GHRH were abolished.

    In plain wordsIn older men, hexarelin still raised growth hormone, while exercise and GHRH alone no longer did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response (AUC) to hexarelin alone in older men
    Study

    n = 6

    Comparator
    Exercise and GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the older group, GH responses to EX and GHRH were abolished (mean AUC: 112, range 0 - 285, and 156, range 30 - 493), respectively) in contrast to the response to Hex (1,077, range 189 - 1,780).
    1 context sentence
    Summary · context
    Twelve male subjects, six in their early-to-mid twenties and six in their late sixties or seventies, received a strong GH stimulus either as incremental EX until volitional exhaustion or by administration of GHRH alone or Hex alone two hours after a presumed maximal GH response to combined administr…

Studies that did not test the peptide alone1

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 03HumanNot a test of Hexarelin aloneNon-randomized trialActivity measurement

    In older men, the GH response to combined GHRH plus hexarelin was about half that of younger men.

    In plain wordsOlder men had about half the growth hormone response of younger men to GHRH given together with hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response (AUC) to GHRH plus hexarelin by age
    Study

    n = 12

    Comparator
    Younger men
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The mean AUC in micro g/l x 120 min to GHRH+Hex in the younger group was approximately twice that in the older group (11,260, range 3,947 - 19,007 vs. 5,366, range 2,262 - 8,654).
    1 context sentence
    Summary · context
    Twelve male subjects, six in their early-to-mid twenties and six in their late sixties or seventies, received a strong GH stimulus either as incremental EX until volitional exhaustion or by administration of GHRH alone or Hex alone two hours after a presumed maximal GH response to combined administr…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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