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Study · Measured the body's own peptide · 2004

3 results

Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells.

Jain AK, Moore SM, Yamaguchi K, Eling TE, Baek SJ

The Journal of pharmacology and experimental therapeutics3 Aug 2004Cited by 10 (Europe PMC)

PMID15292456 (opens in a new tab)DOI10.1124/jpet.104.070664 (opens in a new tab)PepBankPUB-15292456
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In human colorectal cancer cells, selective NSAIDs induced thymosin beta‑4 expression in a time- and concentration-dependent manner.

    In plain wordsIn colorectal cancer cells, some NSAIDs raised the cells' own thymosin beta‑4 expression over time and with dose.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 expression after selective NSAIDs
    Study

    humann: not reported in source

    HCT-116 human colorectal cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    However, only selective NSAIDs induce thymosin beta-4 expression in a time- and concentration-dependent manner.
    1 context sentence
    Summary · context
    Using subtractive hybridization, we previously identified a novel member of the transforming growth factor-beta superfamily that has antitumorigenic activity from indomethacin-treated HCT-116 human colorectal cancer cells.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In human colorectal cancer cells, indomethacin and SC-560 induced thymosin beta‑4 expression.

    In plain wordsIn colorectal cancer cells, indomethacin and SC-560 raised the cells' own thymosin beta‑4 expression.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 expression after indomethacin and SC-560
    Study

    humann: not reported in source

    HCT-116 human colorectal cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    indomethacin and SC-560 [5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole] induce thymosin beta-4 expression
    1 context sentence
    Summary · context
    Using subtractive hybridization, we previously identified a novel member of the transforming growth factor-beta superfamily that has antitumorigenic activity from indomethacin-treated HCT-116 human colorectal cancer cells.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In human colorectal cancer cells, sulindac sulfide did not induce thymosin beta‑4 expression.

    In plain wordsIn colorectal cancer cells, sulindac sulfide did not raise the cells' own thymosin beta‑4 expression.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin beta-4 expression after sulindac sulfide
    Study

    humann: not reported in source

    HCT-116 human colorectal cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    whereas sulindac sulfide does not.
    1 context sentence
    Summary · context
    Using subtractive hybridization, we previously identified a novel member of the transforming growth factor-beta superfamily that has antitumorigenic activity from indomethacin-treated HCT-116 human colorectal cancer cells.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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