Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty. Gonadotropin suppressive effect and final height obtained with two different analogs.

Lanes R, Soros A, Jakubowicz S

Journal of pediatric endocrinology & metabolism : JPEM1 May 2004Cited by 24 (Europe PMC)

PMID15237711DOI10.1515/jpem.2004.17.5.759PepBankPUB-15237711

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, triptorelin suppressed LH slightly more than leuprolide acetate.
In plain wordsIn girls with early puberty, triptorelin suppressed LH slightly more than leuprolide acetate.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH suppression
Study
n: not reported in source
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Adequate gonadotropin suppression (peak level of LH and FSH of <2 IU/l after i.v. GnRH stimulation) was noted with both leuprolide acetate and triptorelin, although LH suppression was slightly more pronounced with triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
Report a problemFND-1523771106
02HumanNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, triptorelin adequately suppressed FSH after GnRH stimulation.
In plain wordsIn girls with early puberty, triptorelin adequately suppressed FSH after GnRH stimulation.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFSH suppression
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Peak FSH after GnRH stimulation
< 2 IU/l
triptorelin, adequate suppression
Source sentences
Summary
Adequate gonadotropin suppression (peak level of LH and FSH of <2 IU/l after i.v. GnRH stimulation) was noted with both leuprolide acetate and triptorelin, although LH suppression was slightly more pronounced with triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
Report a problemFND-1523771107
03HumanNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, bone age advanced less with triptorelin than with leuprolide acetate.
In plain wordsIn girls with early puberty, bone age advanced less with triptorelin than with leuprolide acetate.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseBone age advancement
Study
n: not reported in source
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Bone age advancement
1.5 years
triptorelin (SD 0.3)
Bone age advancement
1.8 years
leuprolide acetate (SD 0.4)
Source sentences
Summary
BA advanced 1.8 +/- 0.4 years during leuprolide acetate treatment and 1.5 +/- 0.3 years with triptorelin, so that FH increased a mean of 5.5 +/- 1.3 cm with leuprolide acetate and 8.7 +/- 2.2 cm with triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
Report a problemFND-1523771108
04HumanNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, height gain was greater with triptorelin than with leuprolide acetate.
In plain wordsIn girls with early puberty, height gain was greater with triptorelin than with leuprolide acetate.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseHeight gain
Study
n: not reported in source
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Final height increase
8.7 cm
triptorelin (SD 2.2)
Final height increase
5.5 cm
leuprolide acetate (SD 1.3)
Source sentences
Summary
BA advanced 1.8 +/- 0.4 years during leuprolide acetate treatment and 1.5 +/- 0.3 years with triptorelin, so that FH increased a mean of 5.5 +/- 1.3 cm with leuprolide acetate and 8.7 +/- 2.2 cm with triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
Report a problemFND-1523771109

Studies that did not test the peptide alone5

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, pooled GnRH analog therapy suppressed gonadotropins while levels increased without treatment.
In plain wordsIn girls with early puberty, pooled GnRH analog therapy suppressed gonadotropins while levels increased without treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseGonadotropin suppression with pooled analogs
Study
n = 37
Comparator
Untreated girls
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
GnRHa therapy suppressed gonadotropins in group A, while gonadotropins increased gradually in group B.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1523771101
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, pooled GnRH analog therapy decreased height velocity while it remained accelerated without treatment.
In plain wordsIn girls with early puberty, pooled GnRH analog therapy decreased growth speed while it remained accelerated without treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHeight velocity with pooled analogs
Study
n = 37
Comparator
Untreated girls
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Height velocity (HV) decreased in group A, while it remained accelerated in group B; BA increased a mean of 1.7 +/- 0.5 years in group A and 3.2 +/- 0.3 years in group B.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1523771102
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, bone age advanced less with pooled GnRH analog therapy than without treatment.
In plain wordsIn girls with early puberty, bone age advanced less with pooled GnRH analog therapy than without treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseBone age advancement with pooled analogs
Study
n = 37
Comparator
Untreated girls
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Bone age advancement
1.7 years
GnRH analog group A (SD 0.5)
Bone age advancement
3.2 years
untreated group B (SD 0.3)
Source sentences
Summary
Height velocity (HV) decreased in group A, while it remained accelerated in group B; BA increased a mean of 1.7 +/- 0.5 years in group A and 3.2 +/- 0.3 years in group B.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1523771103
08HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, final height after pooled GnRH analog therapy exceeded baseline predicted adult height.
In plain wordsIn girls with early puberty, final height after pooled GnRH analog therapy exceeded the initial predicted height.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFinal height versus baseline prediction with pooled analogs
Study
n = 16
Comparator
Baseline predicted adult height
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Predicted adult height at baseline
153.7 cm
GnRH analog group A (SD 1.2)
Final height
160.9 cm
GnRH analog group A (SD 4.0)
Source sentences
Summary
This resulted in a height increase in group A from a baseline PAH of 153.7 +/- 1.2 cm to a final height (FH) of 160.9 +/- 4.0 cm (p <0.001), clearly above their target height (TH) of 157.7 +/- 4.2 cm.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1523771104
09HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In girls with precocious or early puberty, final height after pooled GnRH analog therapy exceeded target height.
In plain wordsIn girls with early puberty, final height after pooled GnRH analog therapy exceeded target height.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFinal height versus target height with pooled analogs
Study
n = 16
Comparator
Target height
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Final height
160.9 cm
GnRH analog group A (SD 4.0)
Target height
157.7 cm
group A (SD 4.2)
Source sentences
Summary
This resulted in a height increase in group A from a baseline PAH of 153.7 +/- 1.2 cm to a final height (FH) of 160.9 +/- 4.0 cm (p <0.001), clearly above their target height (TH) of 157.7 +/- 4.2 cm.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A)
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1523771105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:37 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty. Gonadotropin suppressive effect and final height obtained with two different analogs.

Summary

Results from this study9

Studies that did not test the peptide alone5

Version history

Subjects

Publication types

MeSH terms