Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma.

Wang WS, Chen PM, Hsiao HL, Wang HS, Liang WY, Su Y

Oncogene1 Aug 2004Cited by 83 (Europe PMC)

PMID15235586DOI10.1038/sj.onc.1207888PepBankPUB-15235586

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyMechanism
In matched human samples, Tbeta-4 mRNA levels were relatively higher in metastatic liver lesions than in primary colorectal tumors.
In plain wordsIn human samples, the body's own Tbeta-4 mRNA was higher in liver metastases than in matching primary colon tumors.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta-4 mRNA in liver metastases versus primary tumors
Study
n: not reported in source
matched primary colorectal adenocarcinoma and liver metastases
Comparator
Matched primary colorectal tumors
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Interestingly, the levels of Tbeta-4 mRNA, beta-catenin, c-Myc, and MMP-7 in metastatic liver lesions were relatively higher
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1523558605

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In human SW480 colon carcinoma cells, Tbeta-4 overexpression markedly increased invasiveness.
In plain wordsIn cells, making colon cancer cells produce extra Tbeta-4 markedly raised their ability to invade.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseInvasiveness of Tbeta-4-overexpressing SW480 cells
Study
humann: not reported in source
SW480 colon carcinoma cells overexpressing Tbeta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
A marked increase on the invasiveness in Tbeta-4-overexpressing SW480 cells
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1523558601
03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In human SW480 colon carcinoma cells, Tbeta-4 overexpression increased the levels and activity of matrix metalloproteinase-7.
In plain wordsIn cells, extra Tbeta-4 production raised the level and activity of the enzyme MMP-7.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseMMP-7 levels and activity in Tbeta-4-overexpressing cells
Study
humann: not reported in source
SW480 colon carcinoma cells overexpressing Tbeta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
with increased levels and activity of matrix metalloproteinase-7 (MMP-7) was observed.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1523558602
04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In human SW480 colon carcinoma cells, Tbeta-4 overexpression significantly decreased Fas levels.
In plain wordsIn cells, extra Tbeta-4 production significantly lowered Fas levels.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseFas levels in Tbeta-4-overexpressing cells
Study
humann: not reported in source
SW480 colon carcinoma cells overexpressing Tbeta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Furthermore, the levels of Fas as well as the susceptibility to Fas ligand-mediated apoptosis in Tbeta-4-overexpressing cells were significantly decreased
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1523558603
05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In human SW480 colon carcinoma cells, Tbeta-4 overexpression significantly decreased susceptibility to Fas ligand-mediated apoptosis.
In plain wordsIn cells, extra Tbeta-4 production made the cells significantly less prone to Fas ligand-driven cell death.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSusceptibility to Fas ligand-mediated apoptosis
Study
humann: not reported in source
SW480 colon carcinoma cells overexpressing Tbeta-4
Outcome group
Cell viability and death · Cancer
Source sentences
Summary
the susceptibility to Fas ligand-mediated apoptosis in Tbeta-4-overexpressing cells were significantly decreased
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1523558604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

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