Identification of novel genes regulated by LH in the primate corpus luteum: insight into their regulation during the late luteal phase.

Yadav VK, Muraly P, Medhamurthy R

Molecular human reproduction2 Jul 2004Cited by 26 (Europe PMC)

PMID15235106DOI10.1093/molehr/gah089PepBankPUB-15235106

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In the bonnet monkey corpus luteum, inhibition of LH secretion up-regulated expression of the body's own humanin gene, along with other genes.
In plain wordsIn monkeys, blocking LH raised the activity of the body's own humanin gene in the corpus luteum.
Peptide
Humanin
Outcome
IncreaseHumanin gene expression after inhibition of LH secretion
Study
bonnet monkeyn: not reported in source
Corpus luteum
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The results show that inhibition of LH secretion not only leads to down-regulation in the expression of genes, e.g. low density lipoprotein (LDL) receptor and Aldose reductase, but expression of some of the genes was up-regulated, e.g. Humanin, RNA helicase, Lyric protein, Acidic ribosomal phosphoprotein and KIAA1750
1 context sentence(design, population, supporting numbers)
Summary · context
In an attempt to characterize gonadotrophin (LH)-regulated gene expression in the bonnet monkey corpus luteum (CL), changes in gene expression after GnRH antagonist treatment to inhibit LH secretion, different stages of CL and during hCG-simulated early pregnancy were examined using differential dis…
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1523510601
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In the bonnet monkey corpus luteum, mRNA levels of the genes up-regulated after LH inhibition, which include humanin, were higher in the late luteal phase than in the early and mid-luteal phase.
In plain wordsIn monkeys, the activity of a group of genes that includes the body's own humanin was higher late in the luteal phase.
Peptide
Humanin
Outcome
IncreaseExpression of LH-inhibition up-regulated genes by luteal phase
Study
bonnet monkeyn: not reported in source
Corpus luteum
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
mRNA levels of the genes identified as up-regulated after LH inhibition were higher during late compared to the early and mid-luteal phase CL, but treatment with hCG down-regulated their expressions.
2 context sentences(design, population, supporting numbers)
Summary · context
The results show that inhibition of LH secretion not only leads to down-regulation in the expression of genes, e.g. low density lipoprotein (LDL) receptor and Aldose reductase, but expression of some of the genes was up-regulated, e.g. Humanin, RNA helicase, Lyric protein, Acidic ribosomal phosphoprotein and KIAA1750
Summary · context
In an attempt to characterize gonadotrophin (LH)-regulated gene expression in the bonnet monkey corpus luteum (CL), changes in gene expression after GnRH antagonist treatment to inhibit LH secretion, different stages of CL and during hCG-simulated early pregnancy were examined using differential dis…
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1523510602
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In the bonnet monkey corpus luteum, hCG treatment down-regulated the expression of the genes up-regulated after LH inhibition, which include humanin.
In plain wordsIn monkeys, hCG treatment lowered the activity of a group of genes that includes the body's own humanin.
Peptide
Humanin
Outcome
DecreaseExpression of LH-inhibition up-regulated genes after hCG
Study
bonnet monkeyn: not reported in source
Corpus luteum
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
mRNA levels of the genes identified as up-regulated after LH inhibition were higher during late compared to the early and mid-luteal phase CL, but treatment with hCG down-regulated their expressions.
2 context sentences(design, population, supporting numbers)
Summary · context
The results show that inhibition of LH secretion not only leads to down-regulation in the expression of genes, e.g. low density lipoprotein (LDL) receptor and Aldose reductase, but expression of some of the genes was up-regulated, e.g. Humanin, RNA helicase, Lyric protein, Acidic ribosomal phosphoprotein and KIAA1750
Summary · context
In an attempt to characterize gonadotrophin (LH)-regulated gene expression in the bonnet monkey corpus luteum (CL), changes in gene expression after GnRH antagonist treatment to inhibit LH secretion, different stages of CL and during hCG-simulated early pregnancy were examined using differential dis…
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1523510603

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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