In primary cortical neurons, humanin protected the neurons from cytotoxicity induced by V642I-AbetaPP.
In plain wordsIn nerve cells grown in the lab, humanin protected against cell damage caused by a mutant Alzheimer's-related protein.
- Peptide
- Humanin
- Outcome
- DecreaseV642I-AbetaPP-induced cytotoxicity
- Study
n: not reported in source
Primary cortical neurons- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Two neuroprotective factors, insulin-like growth factor I (IGF-I) and Humanin, protected these primary neurons from V642I-AbetaPP-induced cytotoxicity.
1 context sentence(design, population, supporting numbers)
We analyzed the cytotoxic mechanisms of the London-type AbetaPP mutant, V642I-AbetaPP, in primary cortical neurons utilizing an adenovirus-mediated gene transfer system.