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Study · Other design · n = 7 · 2004

9 results

Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers.

Frieboes RM, Antonijevic IA, Held K, Murck H, Pollmächer T, Uhr M, Steiger A

Psychoneuroendocrinology1 Aug 2004Cited by 22 (Europe PMC)

PMID15177700 (opens in a new tab)DOI10.1016/s0306-4530(03)00152-5 (opens in a new tab)PepBankPUB-15177700
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanOther designEfficacy outcome

    In seven young healthy volunteers, hexarelin decreased stage 4 sleep during the first half of the night versus placebo.

    In plain wordsIn seven healthy young volunteers, hexarelin reduced deep stage 4 sleep early in the night compared with placebo.

    Peptide
    Hexarelin
    Outcome
    DecreaseStage 4 sleep in first half of night
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Following hexarelin, stage 4 sleep during the first half of the night, and EEG delta power during the total night decreased significantly.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  2. 02HumanOther designEfficacy outcome

    In seven young healthy volunteers, hexarelin decreased EEG delta power during the total night versus placebo.

    In plain wordsIn seven healthy young volunteers, hexarelin lowered deep-sleep brain wave power over the night compared with placebo.

    Peptide
    Hexarelin
    Outcome
    DecreaseEEG delta power over the total night
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Following hexarelin, stage 4 sleep during the first half of the night, and EEG delta power during the total night decreased significantly.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  3. 03HumanOther designActivity measurement

    In seven young healthy volunteers, hexarelin increased GH concentrations during the total night versus placebo.

    In plain wordsIn seven healthy young volunteers, hexarelin raised growth hormone levels during the night compared with placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH concentration over the total night
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Significant increases of the concentrations of GH and prolactin during the total night, and of ACTH and of cortisol during the first half of the night were found.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  4. 04HumanOther designActivity measurement

    In seven young healthy volunteers, hexarelin increased prolactin concentrations during the total night versus placebo.

    In plain wordsIn seven healthy young volunteers, hexarelin raised prolactin levels during the night compared with placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseProlactin concentration over the total night
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Significant increases of the concentrations of GH and prolactin during the total night, and of ACTH and of cortisol during the first half of the night were found.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  5. 05HumanOther designActivity measurement

    In seven young healthy volunteers, hexarelin increased ACTH concentrations during the first half of the night versus placebo.

    In plain wordsIn seven healthy young volunteers, hexarelin raised ACTH levels early in the night compared with placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseACTH concentration in first half of night
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Significant increases of the concentrations of GH and prolactin during the total night, and of ACTH and of cortisol during the first half of the night were found.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  6. 06HumanOther designActivity measurement

    In seven young healthy volunteers, hexarelin increased cortisol concentrations during the first half of the night versus placebo.

    In plain wordsIn seven healthy young volunteers, hexarelin raised cortisol levels early in the night compared with placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseCortisol concentration in first half of night
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Significant increases of the concentrations of GH and prolactin during the total night, and of ACTH and of cortisol during the first half of the night were found.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  7. 07HumanOther designActivity measurement

    In seven young healthy volunteers, leptin levels remained unchanged after hexarelin.

    In plain wordsIn seven healthy young volunteers, hexarelin did not change leptin levels compared with placebo.

    Peptide
    Hexarelin
    Outcome
    No significant changeLeptin levels
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Leptin levels, TNF-alpha and soluble TNF receptors remained unchanged.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  8. 08HumanOther designActivity measurement

    In seven young healthy volunteers, TNF-alpha levels remained unchanged after hexarelin.

    In plain wordsIn seven healthy young volunteers, hexarelin did not change the inflammation marker TNF-alpha compared with placebo.

    Peptide
    Hexarelin
    Outcome
    No significant changeTNF-alpha levels
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Leptin levels, TNF-alpha and soluble TNF receptors remained unchanged.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.
  9. 09HumanOther designActivity measurement

    In seven young healthy volunteers, soluble TNF receptor levels remained unchanged after hexarelin.

    In plain wordsIn seven healthy young volunteers, hexarelin did not change soluble TNF receptor levels compared with placebo.

    Peptide
    Hexarelin
    Outcome
    No significant changeSoluble TNF receptor levels
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    4 x 50 microgAs given in this study (human).

    Source sentences

    Summary
    Leptin levels, TNF-alpha and soluble TNF receptors remained unchanged.
    1 context sentence
    Summary · context
    We investigated simultaneously the sleep EEG and nocturnal profiles of GH, ACTH, cortisol, prolactin, leptin, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors in seven young normal volunteers after repetitive administration of 4 x 50 microg hexarelin or placebo at 22.00, 23.00, 24.00 and 01.00 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 12:58 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

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