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Study · In vitro (cell-free) · 2004

3 results

Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study.

Demers A, McNicoll N, Febbraio M, Servant M, Marleau S, Silverstein R, Ong H

The Biochemical journal1 Sept 2004Cited by 80 (Europe PMC)

PMID15176951 (opens in a new tab)PMCIDPMC1133797 (opens in a new tab)DOI10.1042/bj20040036 (opens in a new tab)PepBankPUB-15176951
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In photoaffinity cross-linking experiments, an 8 kDa CD36 fragment (Asn132-Glu177) was identified as the hexarelin-binding site.

    In plain wordsIn lab tests, hexarelin attached to a small stretch of the CD36 protein.

    Peptide
    Hexarelin
    Outcome
    Not applicableHexarelin binding site on CD36
    Study

    n: not reported in source

    Photolabelled CD36 protein
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A 8 kDa photolabelled fragment corresponding to the CD36-(Asn132-Glu177) sequence has been identified as the hexarelin-binding site.
  2. 02LabIn vitro (cell-free)Mechanism

    In photoaffinity cross-linking experiments, CNBr cleavage suggested that Met169 of CD36 is the contact point for hexarelin.

    In plain wordsIn lab tests, hexarelin appeared to touch CD36 at one amino acid, Met169.

    Peptide
    Hexarelin
    Outcome
    Not applicableHexarelin contact point in CD36
    Study

    n: not reported in source

    Photolabelled CD36 protein
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Chemical cleavage of this fragment with CNBr resulted in the release of the free ligand, suggesting that Met169 is the contact point for the ligand within the receptor binding pocket.
    1 context sentence
    Summary · context
    To define the binding domain for hexarelin on CD36, covalent photolabelling of CD36 followed by enzymic and chemical degradation of the photoligand-receptor complex was performed.
  3. 03LabIn vitro (cell-free)Mechanism

    In photoaffinity cross-linking experiments, the hexarelin binding domain on CD36 overlapped with the oxLDL binding domain (residues Gln155-Lys183).

    In plain wordsIn lab tests, the spot on CD36 where hexarelin binds overlaps with the spot where oxidized LDL binds.

    Peptide
    Hexarelin
    Outcome
    Not applicableOverlap of hexarelin and oxLDL binding domains on CD36
    Study

    n: not reported in source

    Photolabelled CD36 protein
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the binding domain for hexarelin on CD36 overlaps with that for oxLDL, which corresponds to residues Gln155-Lys183 of CD36.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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