Ghrelin does not mediate the somatotroph and corticotroph responses to the stimulatory effect of glucagon or insulin-induced hypoglycaemia in humans.

Broglio F, Prodam F, Gottero C, Destefanis S, Me E, Riganti F, Giordano R, Picu A, Balbo M, Van der Lely AJ, Ghigo E, Arvat E

Clinical endocrinology1 Jun 2004Cited by 13 (Europe PMC)

PMID15163333DOI10.1111/j.1365-2265.2004.02038.xPepBankPUB-15163333

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

01HumanNon-randomized trialMechanism
In normal young men, glucagon increased circulating GH (P < 0.01).
In plain wordsIn healthy young men, growth hormone increased after glucagon.
Peptide
Glucagon
Outcome
IncreaseGrowth hormone
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
GLU administration increased (P < 0.01) circulating GH, ACTH and cortisol as well as insulin and glucose levels.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333301
02HumanNon-randomized trialMechanism
In normal young men, glucagon increased circulating ACTH (P < 0.01).
In plain wordsIn healthy young men, ACTH increased after glucagon.
Peptide
Glucagon
Outcome
IncreaseACTH
Study
n = 6
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
GLU administration increased (P < 0.01) circulating GH, ACTH and cortisol as well as insulin and glucose levels.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333302
03HumanNon-randomized trialMechanism
In normal young men, glucagon increased circulating cortisol (P < 0.01).
In plain wordsIn healthy young men, cortisol increased after glucagon.
Peptide
Glucagon
Outcome
IncreaseCortisol
Study
n = 6
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
GLU administration increased (P < 0.01) circulating GH, ACTH and cortisol as well as insulin and glucose levels.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333303
04HumanNon-randomized trialMechanism
In normal young men, glucagon increased circulating insulin (P < 0.01).
In plain wordsIn healthy young men, insulin increased after glucagon.
Peptide
Glucagon
Outcome
IncreaseInsulin
Study
n = 6
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
GLU administration increased (P < 0.01) circulating GH, ACTH and cortisol as well as insulin and glucose levels.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333304
05HumanNon-randomized trialMechanism
In normal young men, glucagon increased circulating glucose (P < 0.01).
In plain wordsIn healthy young men, blood glucose increased after glucagon.
Peptide
Glucagon
Outcome
IncreaseGlucose
Study
n = 6
Outcome group
Glycemic control · Metabolic and weight
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
GLU administration increased (P < 0.01) circulating GH, ACTH and cortisol as well as insulin and glucose levels.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333305
06HumanNon-randomized trialMechanism
In normal young men, the GH increase after glucagon was smaller than after insulin-induced hypoglycemia (P < 0.01).
In plain wordsIn healthy young men, glucagon increased growth hormone less than insulin-induced hypoglycemia.
Peptide
Glucagon
Outcome
DecreaseGH response versus ITT
Study
n = 6
Comparator
insulin-induced hypoglycemia
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
The ITT-induced increases in GH and ACTH, but not cortisol, levels were higher (P < 0.01) than those after GLU.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333306
07HumanNon-randomized trialMechanism
In normal young men, the ACTH increase after glucagon was smaller than after insulin-induced hypoglycemia (P < 0.01).
In plain wordsIn healthy young men, glucagon increased ACTH less than insulin-induced hypoglycemia.
Peptide
Glucagon
Outcome
DecreaseACTH response versus ITT
Study
n = 6
Comparator
insulin-induced hypoglycemia
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
The ITT-induced increases in GH and ACTH, but not cortisol, levels were higher (P < 0.01) than those after GLU.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333307
08HumanNon-randomized trialMechanism
In normal young men, the cortisol increase after insulin-induced hypoglycemia was not higher than after glucagon.
In plain wordsIn healthy young men, insulin-induced hypoglycemia did not increase cortisol more than glucagon.
Peptide
Glucagon
Outcome
No significant changeCortisol response versus ITT
Study
n = 6
Comparator
insulin-induced hypoglycemia
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
The ITT-induced increases in GH and ACTH, but not cortisol, levels were higher (P < 0.01) than those after GLU.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333308
09HumanNon-randomized trialMechanism
In normal young men, glucagon did not modify circulating ghrelin.
In plain wordsIn healthy young men, ghrelin did not change after glucagon.
Peptide
Glucagon
Outcome
No significant changeGhrelin
Study
n = 6
Outcome group
Appetite and food intake · Endocrine and hormones
Studied dose
0.017 mg/kg · intramuscularAs given in this study (human).
Source sentences
Summary
Circulating ghrelin levels were not modified by GLU.
2 context sentences(design, population, supporting numbers)
Summary · context
To this aim we enrolled six normal young male subjects [age (mean +/- SD): 29.0 +/- 8.0 years, body mass index (BMI) 21.9 +/- 2.5 kg/m(2)].
Summary · context
In all the subjects we studied ghrelin, GH, ACTH, cortisol and glucose levels after glucagon (GLU; 0.017 mg/kg intramuscularly), ITT (0.1 IU/kg insulin intravenously) or saline administration.
Report a problemFND-1516333309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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