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Study · Animal study (in vivo) · mouse · 2004

3 results

Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.

Anisimov SV, Khavinson VKh, Anisimov VN

Neuro endocrinology letters1 Feb 2004Cited by 8 (Europe PMC)

PMID15159690 (opens in a new tab)PepBankPUB-15159690
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In female CBA mice, Cortagen changed cardiac expression of 234 clones matching 110 known genes compared with controls.

    In plain wordsIn mice, Cortagen changed cardiac expression of 234 clones matching 110 known genes compared with controls.

    Peptide
    Cortagen (AEDP)
    Outcome
    MixedCardiac transcript expression
    Study

    mousen: not reported in source

    Heart of female 6-months CBA mice
    Comparator
    Control group
    Outcome group
    Gene expression · Cardiovascular
    Studied dose
    Dose not stated · injection · 5 consecutive daysAs given in this study (mouse).

    Measurements

    Clones with significant expression changes
    234 clones
    Cortagen versus control
    Known genes
    110 genes
    Significantly changed clones
    Clones with significant expression changes
    1.53%
    Total clones

    Source sentences

    Summary
    Comparative analysis of cDNA microarray hybridisation with heart samples from control and experimental group revealed 234 clones (1,53% of the total number of clones) with significant changes of expression that matched 110 known genes belonging to various functional categories.
    1 context sentence
    Summary · context
    We therefore analyzed the expression of 15,247 transcripts in the heart of female 6-months CBA mice receiving injections of Cortagen for 5 consecutive days was studied by cDNA microarrays.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In female CBA mice, maximum cardiac gene upregulation after Cortagen was +5.42 compared with controls.

    In plain wordsIn mice, maximum cardiac gene upregulation after Cortagen was +5.42 compared with controls.

    Peptide
    Cortagen (AEDP)
    Outcome
    IncreaseMaximum cardiac gene upregulation
    Study

    mousen: not reported in source

    Heart of female 6-months CBA mice
    Comparator
    Control group
    Outcome group
    Gene expression · Cardiovascular
    Studied dose
    Dose not stated · injection · 5 consecutive daysAs given in this study (mouse).

    Measurements

    Maximum upregulation
    5.42
    Cortagen versus control

    Source sentences

    Summary
    Maximum up- and down-regulation was +5.42 and -2.86, respectively.
    2 context sentences
    Summary · context
    Comparative analysis of cDNA microarray hybridisation with heart samples from control and experimental group revealed 234 clones (1,53% of the total number of clones) with significant changes of expression that matched 110 known genes belonging to various functional categories.
    Summary · context
    We therefore analyzed the expression of 15,247 transcripts in the heart of female 6-months CBA mice receiving injections of Cortagen for 5 consecutive days was studied by cDNA microarrays.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In female CBA mice, maximum cardiac gene downregulation after Cortagen was -2.86 compared with controls.

    In plain wordsIn mice, maximum cardiac gene downregulation after Cortagen was -2.86 compared with controls.

    Peptide
    Cortagen (AEDP)
    Outcome
    DecreaseMaximum cardiac gene downregulation
    Study

    mousen: not reported in source

    Heart of female 6-months CBA mice
    Comparator
    Control group
    Outcome group
    Gene expression · Cardiovascular
    Studied dose
    Dose not stated · injection · 5 consecutive daysAs given in this study (mouse).

    Measurements

    Maximum downregulation
    −2.86
    Cortagen versus control

    Source sentences

    Summary
    Maximum up- and down-regulation was +5.42 and -2.86, respectively.
    2 context sentences
    Summary · context
    Comparative analysis of cDNA microarray hybridisation with heart samples from control and experimental group revealed 234 clones (1,53% of the total number of clones) with significant changes of expression that matched 110 known genes belonging to various functional categories.
    Summary · context
    We therefore analyzed the expression of 15,247 transcripts in the heart of female 6-months CBA mice receiving injections of Cortagen for 5 consecutive days was studied by cDNA microarrays.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 7 to 12Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 6 times, first on 22 Oct 2026, 02:25 UTC. The status did not change between them.

    Study results updated

  2. Version 6

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 5

    21 Oct 2026, 17:05 UTC

    Study results updated

  4. Versions 3 to 4

    21 Oct 2026, 16:35 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  5. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  6. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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