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Study · Animal study (in vivo) · mouse · 2004

2 results

Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin.

Martin NM, Small CJ, Sajedi A, Patterson M, Ghatei MA, Bloom SR

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity1 Jul 2004Cited by 40 (Europe PMC)

PMID15148507 (opens in a new tab)DOI10.1038/sj.ijo.0802646 (opens in a new tab)PepBankPUB-15148507
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pre-obese agouti A(y)/a mice, peripheral NDP-alpha-MSH acutely suppressed feeding at 0-2 h.

    In plain wordsIn pre-obese agouti mice, NDP-alpha-MSH reduced eating in the first two hours.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseFood intake at 0-2 h in pre-obese A(y)/a mice
    Study

    mousen: not reported in source

    agouti A(y)/a mice
    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.2 micromol/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Peripheral administration of NDP-alpha-MSH and leptin acutely suppressed feeding (0-2 h) in pre-obese and obese A(y)/a mice.
    3 context sentences
    Summary · context
    Adult A(y)/a mice were studied in the pre-obese state (7-8 weeks) and obese state (14-15 weeks).
    Summary · context
    Animals received PYY(3-36) (0.02 micromol/kg), NDP-alpha-MSH (0.2 micromol/kg), leptin (2 micromol/kg) (all 24 h fasted state) and ghrelin (0.2 micromol/kg) (fed state) by intraperitoneal (i.p.) injection.
    Summary · context
    Age-matched A(y)/a controls received i.p. saline.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese agouti A(y)/a mice, peripheral NDP-alpha-MSH acutely suppressed feeding at 0-2 h.

    In plain wordsIn obese agouti mice, NDP-alpha-MSH reduced eating in the first two hours.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseFood intake at 0-2 h in obese A(y)/a mice
    Study

    mousen: not reported in source

    agouti A(y)/a mice
    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.2 micromol/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Peripheral administration of NDP-alpha-MSH and leptin acutely suppressed feeding (0-2 h) in pre-obese and obese A(y)/a mice.
    3 context sentences
    Summary · context
    Adult A(y)/a mice were studied in the pre-obese state (7-8 weeks) and obese state (14-15 weeks).
    Summary · context
    Animals received PYY(3-36) (0.02 micromol/kg), NDP-alpha-MSH (0.2 micromol/kg), leptin (2 micromol/kg) (all 24 h fasted state) and ghrelin (0.2 micromol/kg) (fed state) by intraperitoneal (i.p.) injection.
    Summary · context
    Age-matched A(y)/a controls received i.p. saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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