In the mdx mouse muscle cell line, thymosin beta4 was up-regulated, together with other genes, in a microarray comparison with the normal line.
In plain wordsIn mouse muscle cells with the Duchenne model mutation, the body's own thymosin beta4 gene was more active than in normal cells.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseThymosin beta4 expression in mdx muscle cell line
- Study
mousen: not reported in source
skeletal muscle cell lines from mdx and normal mice- Comparator
- Normal mouse muscle cell line
- Outcome group
- Muscle injury and repair · Musculoskeletal
Source sentences
We found that in the mdx muscle cell line, 12 genes, including L-arginine:glycine amidinotransferase and thymosin beta4, are up-regulated, whereas 7 genes, including selenoprotein P and a novel regeneration-associated muscle protease (RAMP), are down-regulated.
1 context sentence(design, population, supporting numbers)
To identify these factors, we searched for mRNAs affected by the mdx mutation by using cDNA microarrays with newly established skeletal muscle cell lines from mdx and normal mice.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.