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Study · Animal study (in vivo) · rat · 2004

3 results

[Effect of a levopromazine-thymalin combination on the development of toxic edema and swelling in the brain].

Platonov IA, Vonogel' VG, Andreeva TA

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2004

PMID15079910 (opens in a new tab)PepBankPUB-15079910
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with toxic brain swelling, thymalin reduced the disorder in plasma protein fractions.

    In plain wordsIn rats with toxic brain swelling, thymalin reduced the disorder in blood protein fractions.

    Peptide
    Thymalin
    Outcome
    DecreasePlasma protein fraction disorder
    Study

    ratn: not reported in source

    Toxic edematous brain swelling
    Outcome group
    Protein and amino acid metabolism · Whole body
    Studied dose
    1.2 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    The administration of levopromazine (5 mg/kg), thymalin (1.2 mg/kg), or their combination reduces this disorder in the blood protein fractions.
    1 context sentence
    Summary · context
    The development of toxic edematous brain swelling in rats is accompanied by disproteinemia of the blood plasma and buildup of the gamma-globulin fraction.

Studies that did not test the peptide alone2

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

  1. 02AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In rats with toxic brain swelling, levopromazine plus thymalin reduced the disorder in plasma protein fractions.

    In plain wordsIn rats with toxic brain swelling, levopromazine plus thymalin reduced the disorder in blood protein fractions.

    Peptide
    Thymalin
    Outcome
    DecreasePlasma protein fraction disorder with combination
    Study

    ratn: not reported in source

    Toxic edematous brain swelling
    Outcome group
    Protein and amino acid metabolism · Whole body

    Source sentences

    Summary
    The administration of levopromazine (5 mg/kg), thymalin (1.2 mg/kg), or their combination reduces this disorder in the blood protein fractions.
    1 context sentence
    Summary · context
    The development of toxic edematous brain swelling in rats is accompanied by disproteinemia of the blood plasma and buildup of the gamma-globulin fraction.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  2. 03AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In rats with toxic brain swelling, levopromazine plus thymalin had an additive synergistic antiedematous effect.

    In plain wordsIn rats with toxic brain swelling, levopromazine plus thymalin had an additive synergistic effect against edema.

    Peptide
    Thymalin
    Outcome
    DecreaseCombination antiedematous effect
    Study

    ratn: not reported in source

    Toxic edematous brain swelling
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The antiedematous effect of the levopromazine--thymalin combination has an additive synergistic interaction.
    1 context sentence
    Summary · context
    The development of toxic edematous brain swelling in rats is accompanied by disproteinemia of the blood plasma and buildup of the gamma-globulin fraction.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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